Consider $N\times N$ hermitian or symmetric random matrices $H$ with independent entries, where the distribution of the $(i,j)$ matrix element is given by the probability measure $\nu_{ij}$ with zero expectation and with variance $\sigma_{ij}^2$. We assume that the variances satisfy the normalization condition $\sum_{i} \sigma^2_{ij} = 1$ for all $j$ and that there is a positive constant $c$ such that $c\le N \sigma_{ij}^2 \le c^{-1}$. We further assume that the probability distributions $\nu_{ij}$ have a uniform subexponential decay. We prove that the Stieltjes transform of the empirical eigenvalue distribution of $H$ is given by the Wigner semicircle law uniformly up to the edges of the spectrum with an error of order $ (N \eta)^{-1}$ where $\eta$ is the imaginary part of the spectral parameter in the Stieltjes transform. There are three corollaries to this strong local semicircle law: (1) Rigidity of eigenvalues: If $\gamma_j =\gamma_{j,N}$ denotes the {\it classical location} of the $j$-th eigenvalue under the semicircle law ordered in increasing order, then the $j$-th eigenvalue $\lambda_j$ is close to $\gamma_j$ in the sense that for any $\xi>1$ there is a constant $L$ such that \[\mathbb P \Big (\exists \, j : \; |\lambda_j-\gamma_j| \ge (\log N)^L \Big [ \min \big (\, j, N-j+1 \, \big) \Big ]^{-1/3} N^{-2/3} \Big) \le C\exp{\big[-c(\log N)^{\xi} \big]} \] for $N$ large enough. (2) The proof of the {\it Dyson's conjecture} \cite{Dy} which states that the time scale of the Dyson Brownian motion to reach local equilibrium is of order $N^{-1}$. (3) The edge universality holds in the sense that the probability distributions of the largest (and the smallest) eigenvalues of two generalized Wigner ensembles are the same in the large $N$ limit provided that the second moments of the two ensembles are identical.

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Consider $N\times N$ Hermitian or symmetric random matrices $H$ where the distribution of the $(i,j)$ matrix element is given by a probability measure $\nu_{ij}$ with a subexponential decay. Let $\sigma_{ij}^2$ be the variance for the probability measure $\nu_{ij}$ with the normalization property that $\sum_{i} \sigma^2_{ij} = 1$ for all $j$. Under essentially the only condition that $c\le N \sigma_{ij}^2 \le c^{-1}$ for some constant $c>0$, we prove that, in the limit $N \to \infty$, the eigenvalue spacing statistics of $H$ in the bulk of the spectrum coincide with those of the Gaussian unitary or orthogonal ensemble (GUE or GOE). We also show that for band matrices with bandwidth $M$ the local semicircle law holds to the energy scale $M^{-1}$.

The stochasticity of gene expression is manifested in the fluctuations of mRNA and protein copy numbers within a cell lineage over time. While data of this type can be obtained for many generations, most mathematical models are unsuitable to interpret such data since they assume non-growing cells. Here we develop a theoretical approach that quantitatively links the frequency content of lineage data to subcellular dynamics. We elucidate how the position, height, and width of the peaks in the power spectrum provide a distinctive fingerprint that encodes a wealth of information about mechanisms controlling transcription, translation, replication, degradation, bursting, promoter switching, cell cycle duration, cell division, gene dosage compensation, and cell size homeostasis. Predictions are confirmed by analysis of single-cell Escherichia coli data obtained using fluorescence microscopy. Furthermore, by matching the experimental and theoretical power spectra, we infer the temperature-dependent gene expression parameters, without the need of measurements relating fluorescence intensities to molecule numbers.