In this paper we discuss properties of the KdV equation under periodic boundary conditions, especially those which are important to study perturbations of the equation. Next we review what is known now about long-time behaviour of solutions for perturbed KdV equations.

We propose a new method for constructing partially hyperbolic diffeomorphisms on closed manifolds. As a demonstration of the method we show that there are simply connected closed manifolds that support partially hyperbolic diffeomorphisms. Laying aside many surgery constructions of 3-dimensional Anosov flows, these are the first new examples of manifolds which admit partially hyperbolic diffeomorphisms in the past forty years.

The main goal of this paper is to understand finer properties of the effective burning velocity from a combustion model introduced by Majda and Souganidis. Motivated by results of Bangert and applications in turbulent combus- tion, we show that when the dimension is two and the flow of the ambient fluid is either weak or very strong, the level set of the effective burning velocity has flat pieces. Due to the lack of an applicable Hopf-type rigidity result, we need to identify the exact location of at least one flat piece. Implications on the effective flame front and other related inverse type problems are also discussed.

We study generalized Hopf–Cole transformations motivated by the Schrödinger bridge problem, which can be seen as a boundary value Hamiltonian system on the Wasserstein space. We prove that generalized Hopf–Cole transformations are symplectic submersions in the Wasserstein symplectic geometry. Many examples, including a Hopf–Cole transformation for the shallow water equations, are given. Based on this transformation, energy splitting inequalities are provided.

This investigation completely classifies the spatial chaos problem in plane edge coloring (Wang tiles) with two symbols. For a set of Wang tiles B, spatial chaos occurs when the spatial entropy h(B) is positive. B is called a minimal cycle generator if P(B) 6= ∅ and P(B′) = ∅ whenever B′ $ B, where P(B) is the set of all periodic patterns on Z2 generated by B. Given a set of Wang tiles B, write B = C1 ∪ C2 ∪ · · · ∪ Ck ∪ N, where Cj, 1 ≤ j ≤ k, are minimal cycle generators and B contains no minimal cycle generator except those contained in C1 ∪ C2 ∪ · · · ∪ Ck. Then, the positivity of spatial entropy h(B) is completely determined by C1 ∪ C2 ∪ · · · ∪ Ck. Furthermore, there are 39 equivalent classes of marginal positive-entropy (MPE) sets of Wang tiles and 18 equivalent classes of saturated zero-entropy (SZE) sets of Wang tiles. For a set of Wang tiles B, h(B) is positive if and only if B contains an MPE set, and h(B) is zero if and only if B is a subset of an SZE set.

We will prove Sarnak’s conjecture on Möbius disjointness for continuous interval maps of zero entropy and also for orientation-preserving circle homeomorphisms by reducing these result to a well-known theorem of Davenport from 1937.

We consider a large class of 2D area-preserving diffeomorphisms that are not uniformly hyperbolic but have strong hyperbolicity properties on large regions of their phase spaces. A prime example is the standard map. Lower bounds for Lyapunov exponents of such systems are very hard to estimate, due to the potential switching of “stable” and “unstable” directions. This paper shows that with the addition of (very) small random perturbations, one obtains with relative ease Lyapunov exponents reflecting the geometry of the deterministic maps.

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Multistep cell fate transitions with stepwise changes of transcriptional profiles are common to many developmental, regenerative and pathological processes. The multiple intermediate cell lineage states can serve as differentiation checkpoints or branching points for channeling cells to more than one lineages. However, mechanisms underlying these transitions remain elusive. Here, we explored gene regulatory circuits that can generate multiple intermediate cellular states with stepwise modulations of transcription factors. With unbiased searching in the network topology space, we found a motif family containing a large set of networks can give rise to four attractors with the stepwise regulations of transcription factors, which limit the reversibility of three consecutive steps of the lineage transition. We found that there is an enrichment of these motifs in a transcriptional network controlling the early T cell development, and a mathematical model based on this network recapitulates multistep transitions in the early T cell lineage commitment. By calculating the energy landscape and minimum action paths for the T cell model, we quantified the stochastic dynamics of the critical factors in response to the differentiation signal with fluctuations. These results are in good agreement with experimental observations and they suggest the stable characteristics of the intermediate states in the T cell differentiation. These dynamical features may help to direct the cells to correct lineages during development. Our findings provide general design principles for multistep cell linage transitions and new insights into the early T cell development. The network motifs containing a large family of topologies can be useful for analyzing diverse biological systems with multistep transitions.

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