Consider an age-dependent, single-species branching process defined by a progeny number distribution, and a lifetime distribution associated with each independent particle. In this paper, we focus on the associated inverse problem where one wishes to formally solve for the progeny number distribution or the lifetime distribution that defines the Bellman-Harris branching process. We derive results for the existence and uniqueness (the identifiability) of these two distributions given one of two types of information: the extinction time probability of the entire process (extinction time distribution), or the distribution of the total number of particles at one fixed time. We demonstrate that perfect knowledge of the distribution of extinction times allows us to formally determine either the progeny number distribution or the lifetime distribution. Furthermore, we show that these constructions are unique. We then consider “data” consisting of a perfectly known total number distribution given at one specific time. For a process with known progeny number distribution and exponentially distributed lifetimes, we show that the rate parameter is identifiable. For general lifetime distributions, we also show that the progeny distribution is globally unique. Our results are presented through four theorems, each describing the constructions in the four distinct cases.

We study generalized Hopf–Cole transformations motivated by the Schrödinger bridge problem, which can be seen as a boundary value Hamiltonian system on the Wasserstein space. We prove that generalized Hopf–Cole transformations are symplectic submersions in the Wasserstein symplectic geometry. Many examples, including a Hopf–Cole transformation for the shallow water equations, are given. Based on this transformation, energy splitting inequalities are provided.

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The stochasticity of gene expression is manifested in the fluctuations of mRNA and protein copy numbers within a cell lineage over time. While data of this type can be obtained for many generations, most mathematical models are unsuitable to interpret such data since they assume non-growing cells. Here we develop a theoretical approach that quantitatively links the frequency content of lineage data to subcellular dynamics. We elucidate how the position, height, and width of the peaks in the power spectrum provide a distinctive fingerprint that encodes a wealth of information about mechanisms controlling transcription, translation, replication, degradation, bursting, promoter switching, cell cycle duration, cell division, gene dosage compensation, and cell size homeostasis. Predictions are confirmed by analysis of single-cell Escherichia coli data obtained using fluorescence microscopy. Furthermore, by matching the experimental and theoretical power spectra, we infer the temperature-dependent gene expression parameters, without the need of measurements relating fluorescence intensities to molecule numbers.

We present a generalization of the method of the local relaxation flow to establish the universality of local spectral statistics of a broad class of large random matrices. We show that the local distribution of the eigenvalues coincides with the local statistics of the corresponding Gaussian ensemble provided the distribution of the individual matrix element is smooth and the eigenvalues ${x_j}_{j=1}^N$ are close to their classical location ${\gamma_j}_{j=1}^N$ determined by the limiting density of eigenvalues. Under the scaling where the typical distance between neighboring eigenvalues is of order 1/N, the necessary apriori estimate on the location of eigenvalues requires only to know that $\E |x_j - \gamma_j |^2 \le N^{-1-\e}$ on average. This information can be obtained by well established methods for various matrix ensembles. We demonstrate the method by proving local spectral universality for Wishart matrices.

We establish necessary and sufficient conditions for consistent root reconstruction in continuous-time Markov models with countable state space on bounded-height trees. Here a root state estimator is said to be consistent if the probability that it returns to the true root state converges to 1 as the number of leaves tends to infinity. We also derive quantitative bounds on the error of reconstruction. Our results answer a question of Gascuel and Steel [GS10] and have implications for ancestral sequence reconstruction in a classical evolutionary model of nucleotide insertion and deletion [TKF91].

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We prove that uniform random quadrangulations of the sphere with$n$faces, endowed with the usual graph distance and renormalized by$n$^{−1/4}, converge as$n$→$∞$in distribution for the Gromov–Hausdorff topology to a limiting metric space. We validate a conjecture by Le Gall, by showing that the limit is (up to a scale constant) the so-called$Brownian map$, which was introduced by Marckert–Mokkadem and Le Gall as the most natural candidate for the scaling limit of many models of random plane maps. The proof relies strongly on the concept of$geodesic stars$in the map, which are configurations made of several geodesics that only share a common endpoint and do not meet elsewhere.

In an infinite sequence of independent identically distributed continuous random variables we study the number of strings of two subsequent records interrupted by a given number of non-records. By embedding in a marked Poisson process we prove that these counts are independent and Poisson distributed. Also the distribution of the number of uninterrupted strings of records is considered.

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