Comparing DNA or protein sequences plays an important role in the functional analysis of genomes. Despite many methods available for sequences comparison, few methods retain the information content of sequences. We propose a new approach, the Yau-Hausdorff method, which considers all translations and rotations when seeking the best match of graphical curves of DNA or protein sequences. The complexity of this method is lower than that of any other two dimensional minimum Hausdorff algorithm. The Yau-Hausdorff method can be used for measuring the similarity of DNA sequences based on two important tools: the Yau-Hausdorff distance and graphical representation of DNA sequences. The graphical representations of DNA sequences conserve all sequence information and the Yau-Hausdorff distance is mathematically proved as a true metric. Therefore, the proposed distance can preciously measure the similarity of DNA sequences. The phylogenetic analyses of DNA sequences by the Yau-Hausdorff distance show the accuracy and stability of our approach in similarity comparison of DNA or protein sequences. This study demonstrates that Yau-Hausdorff distance is a natural metric for DNA and protein sequences with high level of stability. The approach can be also applied to similarity analysis of protein sequences by graphic representations, as well as general two dimensional shape matching.

Varying-coefficient partially linear models are frequently used in statistical modelling, but their estimation and inference have not been systematically studied. This paper proposes a profile least-squares technique for estimating the parametric component and studies the asymptotic normality of the profile least-squares estimator. The main focus is the examination of whether the generalized likelihood technique developed by Fan et al. is applicable to the testing problem for the parametric component of semiparametric models. We introduce the profile likelihood ratio test and demonstrate that it follows an asymptotically 2 distribution under the null hypothesis. This not only unveils a new Wilks type of phenomenon, but also provides a simple and useful method for semiparametric inferences. In addition, the Wald statistic for semiparametric models is introduced and demonstrated to possess a sampling property similar

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Deconvolution problems arise in a variety of situations in statistics. An interesting problem is to estimate the density f of a random variable X based on n i.i.d. observations from Y = X + , where is a measurement error with a known distribution. In this paper, the effect of errors in variables of nonparametric deconvolution is examined. Insights are gained by showing that the difficulty of deconvolution depends on the smoothness of error distributions: the smoother, the harder. In fact, there are two types of optimal rates of convergence according to whether the error distribution is ordinary smooth or supersmooth. It is shown that optimal rates of convergence can be achieved by deconvolution kernel density estimators.

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We consider the edge statistics of large dimensional deformed rectangular matrices of the form $Y_t=Y+\sqrt{t}X,$ where $Y$ is a $p \times n$ deterministic signal matrix whose rank is comparable to $n$, $X$ is a $p\times n$ random noise matrix with centered i.i.d. entries with variance $n^{-1}$, and $t>0$ gives the noise level. This model is referred to as the interference-plus-noise matrix in the study of massive multiple-input multiple-output (MIMO) system, which belongs to the category of the so-called signal-plus-noise model. For the case $t=1$, the spectral statistics of this model have been studied to a certain extent in the literature \cite{DOZIER20071099,DOZIER2007678,VLM2012}. In this paper, we study the singular value and singular vector statistics of $Y_t$ around the right-most edge of the singular value spectrum in the harder regime $n^{-2/3}\ll t \ll 1$. This regime is harder than the $t=1$ case, because on one hand, the edge behavior of the empirical spectral distribution (ESD) of $YY^\top$ has a strong effect on the edge statistics of $Y_tY_t^\top$ since $t\ll 1$ is ``small", while on the other hand, the edge statistics of $Y_t$ is also not merely a perturbation of those of $Y$ since $t\gg n^{-2/3}$ is ``large". Under certain regularity assumptions on $Y,$ we prove the edge universality, eigenvalues rigidity and eigenvector delocalization for the matrices $Y_tY_t^\top$ and $Y_t^\top Y_t$. These results can be used to estimate and infer the massive MIMO system. To prove the main results, we analyze the edge behavior of the asymptotic ESD for $Y_tY_t^\top$, and establish some sharp local laws on the resolvent of $Y_tY_t^\top$. These results can be of independent interest, and used as useful inputs for many other problems regarding the spectral statistics of $Y_t$.

Community detection is a fundamental problem in social network analysis. It is desirable to have fast community detection algorithm that applicable to large-scale networks we see today and also have reliable community detection results. This paper proposes Spectral Clustering On Ratios-of-eigenvectors (SCORE) as such an algorithm. The algorithm is fast in computation, is applicable to real large networks, and is competitive in real data performance when applied to some representative data sets in this area. We study the algorithm with the Degree-Corrected Block Model (DCBM). Compare to most works in this area that focus on the much narrower Block Models, our analysis is more difficult and requires new techniques. The novelty of our algorithm lies in that it uses entry-wise ratios between leading eigenvectors of the adjacency to reduce a seemingly hard problem to a problem that is very much tractable.

We establish necessary and sufficient conditions for consistent root reconstruction in continuous-time Markov models with countable state space on bounded-height trees. Here a root state estimator is said to be consistent if the probability that it returns to the true root state converges to 1 as the number of leaves tends to infinity. We also derive quantitative bounds on the error of reconstruction. Our results answer a question of Gascuel and Steel [GS10] and have implications for ancestral sequence reconstruction in a classical evolutionary model of nucleotide insertion and deletion [TKF91].