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The skeleton of a 2D shape is an important geometric structure in pattern analysis and computer vision. In this paper we study the skeleton of a 2D shape in a two-manifold M, based on a geodesic metric. We present a formal definition of the skeleton S(\Omega) for a shape V in M and show several properties that make S(\Omega) distinct from its Euclidean counterpart in R^2. We further prove that for a shape sequence {\Omega_i} that converge to a shape V in M, the mapping \Omega\rightarrow S(\Omega_i) is lower semi-continuous. A direct application of this result is that we can use a set P of sample points to approximate the boundary of a 2D shape V in M, and the Voronoi diagram of P inside \Omega\subset M gives a good approximation to the skeleton S(\Omega). Examples of skeleton computation in topography and brain morphometry are illustrated.

2D shape sequence, Voronoi skeleton, two-manifold, geodesic