A novel approach on protein classification

Xiaogeng Wan Tsinghua University Xin Zhao Tsinghua University Stephen S. -T. Yau Tsinghua University

General Mathematics mathscidoc:1610.13001

Protein universe is a complex system with critical problem of protein evolution to be analyzed. Early studies have used geometric distances and polygenetic-trees to solve this problem. However, the traditional methods are bivariate, whose taxonomy classification relies on bivariate branching. This is not sufficient to describe the complex nature of protein universe. Therefore, we propose a novel approach on multivariate protein classification. The new method bases on the theory of information and network, can be used to analyze multivariate relationships of proteins. The new method is alignment-free and have wide-applications to both sequences and 3D structures. We demonstrate the new method on six protein examples, results show that the new method is efficient and can potentially be used for future protein classifications.
Protein classification, information, network, sequence, evolution.
[ Download ] [ 2016-10-25 22:05:48 uploaded by StephenYau ] [ 652 downloads ] [ 0 comments ]
  title={A novel approach on protein classification},
  author={Xiaogeng Wan, Xin Zhao, and Stephen S. -T. Yau},
Xiaogeng Wan, Xin Zhao, and Stephen S. -T. Yau. A novel approach on protein classification. 2016. http://archive.ymsc.tsinghua.edu.cn/pacm_paperurl/20161025220548831366600.
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