MathSciDoc: An Archive for Mathematician ∫

 
Log In
Sign Up
Help
Go
 

Full Chromosomal Relationships Between Populations and the Origin of Humans

Rui Dong Yau Mathematical Sciences Center, Tsinghua University, Beijing, China; Yanqi Lake Beijing Institute of Mathematical Sciences and Applications, Beijing, China Shaojun Pei Department of Mathematical Sciences, Tsinghua University, Beijing, China Mengcen Guan Department of Mathematical Sciences, Tsinghua University, Beijing, China Shek-Chung Yau Information Technology Services Center, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, China Changchuan Yin Department of Mathematics, Statistics and Computer Science, University of Illinois at Chicago, Chicago, IL, United States Rong L. He Department of Biological Sciences, Chicago State University, Chicago, IL, United States Stephen S.-T. Yau Department of Mathematical Sciences, Tsinghua University, Beijing, China; Yanqi Lake Beijing Institute of Mathematical Sciences and Applications, Beijing, China

Data Analysis, Bio-Statistics, Bio-Mathematics mathscidoc:2204.42001

Frontiers in Genetics, 12, 828805, 2022.2
A comprehensive description of human genomes is essential for understanding human evolution and relationships between modern populations. However, most published literature focuses on local alignment comparison of several genes rather than the complete evolutionary record of individual genomes. Combining with data from the 1,000 Genomes Project, we successfully reconstructed 2,504 individual genomes and propose Divided Natural Vector method to analyze the distribution of nucleotides in the genomes. Comparisons based on autosomes, sex chromosomes and mitochondrial genomes reveal the genetic relationships between populations, and different inheritance pattern leads to different phylogenetic results. Results based on mitochondrial genomes confirm the “out-of-Africa” hypothesis and assert that humans, at least females, most likely originated in eastern Africa. The reconstructed genomes are stored on our server and can be further used for any genome-scale analysis of humans (http://yaulab.math.tsinghua.edu.cn/2022_1000genomesprojectdata/). This project provides the complete genomes of thousands of individuals and lays the groundwork for genome-level analyses of the genetic relationships between populations and the origin of humans.
No keywords uploaded!
[ Download ] [ 2022-04-28 14:34:20 uploaded by dongrui ] [ 1398 downloads ] [ 0 comments ] 
@inproceedings{rui2022full,
  title={Full Chromosomal Relationships Between Populations and the Origin of Humans},
  author={Rui Dong, Shaojun Pei, Mengcen Guan, Shek-Chung Yau, Changchuan Yin, Rong L. He, and Stephen S.-T. Yau},
  url={http://archive.ymsc.tsinghua.edu.cn/pacm_paperurl/20220428143420322567147},
  booktitle={Frontiers in Genetics},
  volume={12},
  pages={828805},
  year={2022},
}
Rui Dong, Shaojun Pei, Mengcen Guan, Shek-Chung Yau, Changchuan Yin, Rong L. He, and Stephen S.-T. Yau. Full Chromosomal Relationships Between Populations and the Origin of Humans. 2022. Vol. 12. In Frontiers in Genetics. pp.828805. http://archive.ymsc.tsinghua.edu.cn/pacm_paperurl/20220428143420322567147.
Please log in for comment!
 
 
Contact us: office-iccm@tsinghua.edu.cn | Copyright Reserved