Apoptotic cells protect mice against lipopolysaccharide-induced shock

Yi Ren Yi Xie Guoping Jiang Jianqing Fan Joseph Yeung Wen Li Paul KH Tam John Savill

Data Analysis mathscidoc:1912.43295

The Journal of Immunology, 180, (7), 4978-4985, 2008.4
LPS is a main causative agent of septic shock. There is a lack of effective therapies. In vitro studies have shown that uptake of apoptotic cells actively inhibits the secretion by activated macrophages (M) of proinflammatory mediators such as TNF- and that such uptake increases the antiinflammatory and immunosuppressive cytokine TGF-. We therefore investigated the protective effect of apoptotic cells against LPS-induced endotoxic shock in mice. The current report is the first study to demonstrate that administration of apoptotic cells can protect mice from LPS-induced death, even when apoptotic cells were administered 24 h after LPS challenge. The beneficial effects of administration of apoptotic cells included 1) reduced circulating proinflammatory cytokines, 2) suppression of polymorphonuclear neutrophil infiltration in target organs, and 3) decreased serum LPS levels. LPS can quickly bind to apoptotic cells
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@inproceedings{yi2008apoptotic,
  title={Apoptotic cells protect mice against lipopolysaccharide-induced shock},
  author={Yi Ren, Yi Xie, Guoping Jiang, Jianqing Fan, Joseph Yeung, Wen Li, Paul KH Tam, and John Savill},
  url={http://archive.ymsc.tsinghua.edu.cn/pacm_paperurl/20191221113537969290855},
  booktitle={The Journal of Immunology},
  volume={180},
  number={7},
  pages={4978-4985},
  year={2008},
}
Yi Ren, Yi Xie, Guoping Jiang, Jianqing Fan, Joseph Yeung, Wen Li, Paul KH Tam, and John Savill. Apoptotic cells protect mice against lipopolysaccharide-induced shock. 2008. Vol. 180. In The Journal of Immunology. pp.4978-4985. http://archive.ymsc.tsinghua.edu.cn/pacm_paperurl/20191221113537969290855.
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