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Macrophages in spinal cord injury: phenotypic and functional change from exposure to myelin debris

Xi Wang Kai Cao Xin Sun Yongxiong Chen Zhaoxia Duan Li Sun Lei Guo Paul Bai Dongming Sun Jianqing Fan Xijing He Wise Young Yi Ren

Data Analysis mathscidoc:1912.43310

Glia, 63, (4), 635-651, 2015.4
Macrophage activation and persistent inflammation contribute to the pathological process of spinal cord injury (SCI). It was reported that M2 macrophages were induced at 37 days after SCI but M2 markers were reduced or eliminated after 1 week. By contrast, M1 macrophage response is rapidly induced and then maintained at injured spinal cord. However, factors that modulate macrophage phenotype and function are poorly understood. We developed a model to distinguish bonemarrow derived macrophages (BMDMs) from residential microglia and explored how BMDMs change their phenotype and functions in response to the lesionrelated factors in injured spinal cord. Infiltrating BMDMs expressing higher Mac2 and lower CX3CR1 migrate to the epicenter of injury, while microglia expressing lower Mac2 but higher CX3CR1 distribute to the edges of lesion. Myelin debris at the lesion site switches BMDMs
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@inproceedings{xi2015macrophages,
  title={Macrophages in spinal cord injury: phenotypic and functional change from exposure to myelin debris},
  author={Xi Wang, Kai Cao, Xin Sun, Yongxiong Chen, Zhaoxia Duan, Li Sun, Lei Guo, Paul Bai, Dongming Sun, Jianqing Fan, Xijing He, Wise Young, and Yi Ren},
  url={http://archive.ymsc.tsinghua.edu.cn/pacm_paperurl/20191221113630239154870},
  booktitle={Glia},
  volume={63},
  number={4},
  pages={635-651},
  year={2015},
}
Xi Wang, Kai Cao, Xin Sun, Yongxiong Chen, Zhaoxia Duan, Li Sun, Lei Guo, Paul Bai, Dongming Sun, Jianqing Fan, Xijing He, Wise Young, and Yi Ren. Macrophages in spinal cord injury: phenotypic and functional change from exposure to myelin debris. 2015. Vol. 63. In Glia. pp.635-651. http://archive.ymsc.tsinghua.edu.cn/pacm_paperurl/20191221113630239154870.
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