The use of proteomics in the discovery of serum biomarkers from patients with severe acute respiratory syndrome

Yi Ren QingYu He Jianqing Fan Brian Jones Yuan Zhou Yi Xie ChungYan Cheung Adrian Wu JenFu Chiu JS Malik Peiris Paul Kwong Hang Tam

Data Analysis mathscidoc:1912.43329

Proteomics, 4, (11), 3477-3484, 2004.11
Severe acute respiratory syndrome (SARS) is a new infectious disease with a global impact. Understanding its pathogenesis and developing specific diagnostic methods for its early diagnosis are crucial for the effective management and control of this disease. By using proteomic technology, truncated forms of <sub>1</sub>antitrypsin (TF<sub>1</sub>AT) were found to increase significantly and consistently in sera of SARS patients compared to control subjects. The result showed a sensitivity of 100% for SARS patients and a specificity of 92.8% for controls. Furthermore, the levels of these proteins significantly correlated with certain clinicopathological parameters. The dramatic increase in TF<sub>1</sub>AT may be the result of degradation of <sub>1</sub>AT. As <sub>1</sub>AT plays an important role in the protection of lung function, its degradation may be an important factor in the pathogenesis of SARS. These findings indicate that increased TF<sub>1</sub>AT
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@inproceedings{yi2004the,
  title={The use of proteomics in the discovery of serum biomarkers from patients with severe acute respiratory syndrome},
  author={Yi Ren, QingYu He, Jianqing Fan, Brian Jones, Yuan Zhou, Yi Xie, ChungYan Cheung, Adrian Wu, JenFu Chiu, JS Malik Peiris, and Paul Kwong Hang Tam},
  url={http://archive.ymsc.tsinghua.edu.cn/pacm_paperurl/20191221113738013305889},
  booktitle={Proteomics},
  volume={4},
  number={11},
  pages={3477-3484},
  year={2004},
}
Yi Ren, QingYu He, Jianqing Fan, Brian Jones, Yuan Zhou, Yi Xie, ChungYan Cheung, Adrian Wu, JenFu Chiu, JS Malik Peiris, and Paul Kwong Hang Tam. The use of proteomics in the discovery of serum biomarkers from patients with severe acute respiratory syndrome. 2004. Vol. 4. In Proteomics. pp.3477-3484. http://archive.ymsc.tsinghua.edu.cn/pacm_paperurl/20191221113738013305889.
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