Involvement of visinin-like protein-1 (VSNL-1) in regulating proliferative and invasive properties of neuroblastoma

Yi Xie Hiuman Chan Jianqing Fan Yongxiong Chen Joseph Young Wen Li Xiaoping Miao Zhengwei Yuan Huanmin Wang Paul KH Tam Yi Ren

Data Analysis mathscidoc:1912.43377

Carcinogenesis, 28, (10), 2122-2130, 2007.7
Tumor growth and metastasis require that tumor cells must have either the potential to shift genetically or epigenetically between proliferative and invasive phenotypes or both phenotypes simultaneously. In the present study, we demonstrated that neuroblastoma growth and invasion were distinct processes that were carried out by proliferative and invasive phenotypes of tumor cells, respectively. Two subpopulations from human neuroblastoma cell line were isolated: highly invasive (HI) cells and low-invasive (LI) cells. HI and LI cells had different proliferative rate and metastatic ability <i>in vitro</i> and <i>in vivo</i> . In addition, they had distinct activated signal pathways and sensitivities to chemotherapy drugs. Affymetrix microarray and quantitative reverse transcriptasepolymerase chain reaction revealed that visinin-like protein-1 (VSNL-1) mRNA in HI cells was significantly higher than
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@inproceedings{yi2007involvement,
  title={Involvement of visinin-like protein-1 (VSNL-1) in regulating proliferative and invasive properties of neuroblastoma},
  author={Yi Xie, Hiuman Chan, Jianqing Fan, Yongxiong Chen, Joseph Young, Wen Li, Xiaoping Miao, Zhengwei Yuan, Huanmin Wang, Paul KH Tam, and Yi Ren},
  url={http://archive.ymsc.tsinghua.edu.cn/pacm_paperurl/20191221114036045932937},
  booktitle={Carcinogenesis},
  volume={28},
  number={10},
  pages={2122-2130},
  year={2007},
}
Yi Xie, Hiuman Chan, Jianqing Fan, Yongxiong Chen, Joseph Young, Wen Li, Xiaoping Miao, Zhengwei Yuan, Huanmin Wang, Paul KH Tam, and Yi Ren. Involvement of visinin-like protein-1 (VSNL-1) in regulating proliferative and invasive properties of neuroblastoma. 2007. Vol. 28. In Carcinogenesis. pp.2122-2130. http://archive.ymsc.tsinghua.edu.cn/pacm_paperurl/20191221114036045932937.
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