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In this paper, we show that any compact K\"ahler manifold homotopic to a compact Riemannian manifold with negative sectional curvature admits a K\"ahler-Einstein metric of general type. Moreover, we prove that, on a compact symplectic manifold $X$ homotopic to a compact Riemannian manifold with negative sectional curvature, for any almost complex structure $J$ compatible with the symplectic form, there is no non-constant $J$-holomorphic entire curve $f:\C\> X$.

In [10], R. Hamilton established a differential Harnack inequality for solutions to the Ricci flow with nonnegative curvature operator. We show that this inequality holds under the weaker condition that M × R2 has nonnegative isotropic curvature.

By using certain idea developed in minimal submanifold theory we study rigidity problem for self-shrinkers in the present paper. We prove rigidity results for the squared norm of the second fundamental form of self-shrinkers, either under point-wise conditions or under integral conditions.

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