The stochasticity of gene expression is manifested in the fluctuations of mRNA and protein copy numbers within a cell lineage over time. While data of this type can be obtained for many generations, most mathematical models are unsuitable to interpret such data since they assume non-growing cells. Here we develop a theoretical approach that quantitatively links the frequency content of lineage data to subcellular dynamics. We elucidate how the position, height, and width of the peaks in the power spectrum provide a distinctive fingerprint that encodes a wealth of information about mechanisms controlling transcription, translation, replication, degradation, bursting, promoter switching, cell cycle duration, cell division, gene dosage compensation, and cell size homeostasis. Predictions are confirmed by analysis of single-cell Escherichia coli data obtained using fluorescence microscopy. Furthermore, by matching the experimental and theoretical power spectra, we infer the temperature-dependent gene expression parameters, without the need of measurements relating fluorescence intensities to molecule numbers.
We present an integral representation for the tensor product L-function of a pair of automorphic cuspidal representations, one of a classical group, the other of a general linear group. Our construction is uniform over all classical groups, and is applicable to all cuspidal representations; it does not require genericity. The main new ideas of the construction are the use of generalized Speh representations as inducing data for the Eisenstein series and the introduction of a new (global and local) model, which generalizes the Whittaker model. Here we consider linear groups, but our construction also extends to arbitrary degree metaplectic coverings; this will be the topic of an upcoming work.
Let F be a non-Archimedean local field. This paper studies homological properties of irreducible smooth representations restricted from GLn+1(F) to GLn(F). A main result shows that each Bernstein component of an irreducible smooth representation of GLn+1(F) restricted to GLn(F) is indecomposable. We also classify all irreducible representations which are projective when restricting from GLn+1(F) to GLn(F). A main tool of our study is a notion of left and right derivatives, extending some previous work joint with Gordan Savin. As a by-product, we also determine the branching law in the opposite direction.
This article focuses on the characterization of global multiple Schramm– Loewner evolutions (SLE). The chordal SLE describes the scaling limit of a single interface in various critical lattice models with Dobrushin boundary conditions, and similarly, global multiple SLEs describe scaling limits of collections of interfaces in critical lattice models with alternating boundary conditions. In this article, we give a minimal amount of characterizing properties for the global multiple SLEs: we prove that there exists a unique probability measure on collections of pairwise disjoint continuous simple curves with a certain conditional law property. As a consequence, we obtain the convergence of multiple interfaces in the critical Ising, FK-Ising and percolation models.