We prove some structure results for transversely reducible Sasaki manifolds. In particular, we show a Sasaki manifold with positive Ricci curvature is transversely irreducible, and so join (product) construction cannot be generalized to irregular SasakiEinstein manifolds, as opposed to the quasi-regular case done by WangZiller and BoyerGalicki. As an application, we classify compact Sasaki manifolds with nonnegative transverse bisectional curvature, which can be viewed as the generalized Frankel conjecture in Sasaki geometry.