Let Y be a non-singular projective manifold with an ample canonical sheaf, and let V be a Q-variation of Hodge structures of
weight one on Y with Higgs bundle E1,0 ⊕ E0,1, coming from a family of Abelian varieties. If Y is a curve the Arakelov inequality
says that the slopes satisfy μ(E1,0) − μ(E0,1) ≤ μ(1 Y ).
We prove a similar inequality in the higher dimensional case. If the latter is an equality, and if the discriminant of E1,0 or the
one of E0,1 is zero, one hopes that Y is a Shimura variety, and V a uniformizing variation of Hodge structures. This is verified, in
case the universal covering of Y does not contain factors of rank> 1. Part of the results extend to variations of Hodge structures
over quasi-projective manifolds U.