Let X and Y be locally compact Hausdorff spaces. We give a full description of disjointness preserving Fredholm linear operators T from C0(X) into C0(Y), and show that is continuous if either Y contains no isolated point or T has closed range. Our task is achieved by writing T as a weighted composition operator Tf = h f . Through the relative homeomorphism , the structure of the range space of T can be completely analyzed, and X and Y are homeomorphic after removing finite subsets.