We demonstrate how path integrals often used in problems of theoretical physics can be adapted to provide a machinery for performing Bayesian inference in function spaces. Such inference comes about naturally in the study of inverse problems of recovering continuous (infinite dimensional) coefficient functions from ordinary or partial differential equations, a problem which is typically ill-posed. Regularization of these problems using L2 function spaces (Tikhonov regularization) is equivalent to Bayesian probabilistic inference, using a Gaussian prior. The Bayesian interpretation of inverse problem regularization is useful since it allows one to quantify and characterize error and degree of precision in the solution of inverse problems, as well as examine assumptions made in solving the problem—namely whether the subjective choice of regularization is compatible with prior knowledge. Using path-integral formalism, Bayesian inference can be explored through various perturbative techniques, such as the semiclassical approximation, which we use in this manuscript. Perturbative path-integral approaches, while offering alternatives to computational approaches like Markov-Chain-Monte-Carlo (MCMC), also provide natural starting points for MCMC methods that can be used to refine approximations. In this manuscript, we illustrate a path-integral formulation for inverse problems and demonstrate it on an inverse problem in membrane biophysics as well as inverse problems in potential theories involving the Poisson equation.

A familiar anomaly affects SU(2) gauge theory in four dimensions: a theory with an odd number of fermion multiplets in the spin 1/2 representation of the gauge group, and more generally in representations of spin 2r+1/2, is inconsistent. We describe here a more subtle anomaly that can affect SU(2) gauge theory in four dimensions under the condition that fermions transform with half-integer spin under SU(2) and bosons with integer spin. Such a theory, formulated in a way that requires no choice of spin structure, and with an odd number of fermion multiplets in representations of spin 4r+3/2, is inconsistent. The theory is consistent if one picks a spin or spin_c structure. Under Higgsing to U(1), the new SU(2) anomaly reduces to a known anomaly of "all-fermion electrodynamics." Like that theory, an SU(2) theory with an odd number of fermion multiplets in representations of spin 4r+3/2 can provide a boundary state for a five-dimensional gapped theory whose partition function on a closed five-manifold Y is (−1)^{∫_Y w2w3}. All statements have analogs with SU(2) replaced by Sp(2N). There is also an analog in five dimensions.

In a recent paper we quantized the interaction of gravity with a Yang-Mills and Higgs field and obtained as a result a gravitational wave equation in a globally hyperbolic spacetime. Assuming that the Cauchy hypersurfaces are compact we proved a spectral resolution for the wave equation by applying the method of separation of variables. In this paper we extend the results to the case when the Cauchy hypersurfaces are non-compact by considering a Gelfand triplet and applying the nuclear spectral theorem.

Into a geometric setting, we import the physical interpretation of index theorems via semi-classical analysis in topological quantum field theory. We develop a direct relationship between Fedosov’s deformation quantization of a symplectic manifold X and the Batalin-Vilkovisky (BV) quantization of a one-dimensional sigma model with target X. This model is a quantum field theory of AKSZ type and is quantized rigorously using Costello’s homotopic theory of effective renormalization. We show that Fedosov’s Abelian connections on the Weyl bundle produce solutions to the effective quantum master equation. Moreover, BV integration produces a natural trace map on the deformation quantized algebra. This formulation allows us to exploit a (rigorous) localization argument in quantum field theory to deduce the algebraic index theorem via semi-classical analysis, i.e., one-loop Feynman diagram computations.

We show that the category of finite-length generalized modules for the singlet vertex algebra M(p), p∈Z_+, is equal to the category O_M(p) of C_1-cofinite M(p)-modules, and that this category admits the vertex algebraic braided tensor category structure of Huang-Lepowsky-Zhang. Since O_M(p) includes the uncountably many typical M(p)-modules, which are simple M(p)-module structures on Heisenberg Fock modules, our results substantially extend our previous work on tensor categories of atypical M(p)-modules. We also introduce a tensor subcategory O_M(p)^T, graded by an algebraic torus T, which has enough projectives and is conjecturally tensor equivalent to the category of finite-dimensional weight modules for the unrolled restricted quantum group of sl_2 at a 2pth root of unity. We compute all tensor products involving simple and projective M(p)-modules, and we prove that both tensor categories O_M(p) and O_M(p)^T are rigid and thus also ribbon. As an application, we use vertex operator algebra extension theory to show that the representation categories of all finite cyclic orbifolds of the triplet vertex algebras W(p) are non-semisimple modular tensor categories, and we confirm a conjecture of Adamović-Lin-Milas on the classification of simple modules for these finite cyclic orbifolds.