In this paper, we present an efficient attack to the multivariate Quadratic Quasigroups (MQQ) cryptosystem. Our cryptanalysis breaks MQQ cryptosystems by solving systems of multivariate quadratic polynomial equations using a modified version of the MutantXL algorithm. We present experimental results comparing the behavior of our implementation of MutantXL to Magma's implementation of F_4 on MQQ systems (\ge 135 bit). Based on our results we show that the MutantXL implementation solves with much less memory than Magma's implementation of F_4 algorithm.

We discuss a pair of isoperimetric problems which at a glance seem to be unrelated. The first one is classical: one places N identical point charges at a closed curve T at the same arc-length distances and asks about the energy minimum, ie which shape does the loop take if left by itself. The second problem comes from quantum mechanics: we take a Schrdinger operator in

The structural variations of multidomain proteins with flexible parts mediate many biological processes, and a structure ensemble can be determined by selecting a weighted combination of representative structures from a simulated structure pool, producing the best fit to experimental constraints such as interatomic distance. In this study, a hybrid structure-based and physics-based atomistic force field with an efficient sampling strategy is adopted to simulate a model di-domain protein against experimental paramagnetic relaxation enhancement (PRE) data that correspond to distance constraints. The molecular dynamics simulations produce a wide range of conformations depicted on a protein energy landscape. Subsequently, a conformational ensemble recovered with low-energy structures and the minimum-size restraint is identified in good agreement with experimental PRE rates, and the result is also supported by chemical shift perturbations and small-angle X-ray scattering data. It is illustrated that the regularizations of energy and ensemble-size prevent an arbitrary interpretation of protein conformations. Moreover, energy is found to serve as a critical control to refine the structure pool and prevent data overfitting, because the absence of energy regularization exposes ensemble construction to the noise from high-energy structures and causes a more ambiguous representation of protein conformations. Finally, we perform structure-ensemble optimizations with a topology-based structure pool, to enhance the understanding on the ensemble results from different sources of pool candidates.

We propose a new basic trapdoor ℓIC (ℓ-Invertible Cycles) of the mixed field type for Multivariate Quadratic public key cryptosystems. This is the first new basic trapdoor since the invention of Unbalanced Oil and Vinegar in 1997. ℓIC can be considered an extended form of the well-known Matsumoto-Imai Scheme A (also MIA or C^∗), and share some features of stagewise triangular systems. However ℓIC has very distinctive properties of its own. In practice, ℓIC is much faster than MIA, and can even match the speed of single-field MQ schemes.

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