In this paper, we study smooth complex projective varieties X such that some exterior power ⋀^rT_X of the tangent bundle is strictly nef. We prove that such varieties are rationally connected. We also classify the following two cases. If T_X is strictly nef, then X isomorphic to the projective space P^n. If ⋀^2T_X is strictly nef and if X has dimension at least 3, then X is either isomorphic to P^n or a quadric Q^n.