There is an unmet medical need to identify neuroimaging biomarkers that allow us to accurately diagnose and monitor Alzheimer's disease (AD) at its very early stages and to assess the response to AD-modifying therapies. To a certain extent, volumetric and functional magnetic resonance imaging (fMRI) studies can detect changes in structure, cerebral blood flow, and blood oxygenation that distinguish AD and mild cognitive impairment (MCI) subjects from healthy control (HC) subjects. However, it has been challenging to use fully automated MRI analytic methods to identify potential AD neuroimaging biomarkers. We have thus proposed a method based on independent component analysis (ICA) for studying potential AD-related MR image features that can be coupled with the use of support vector machine (SVM) for classifying scans into categories of AD, MCI, and HC subjects. The MRI data were selected from

Computing uniformization maps for surfaces has been a challenging problem and has many practical applications. In this paper, we provide a theoretically rigorous algorithm to compute such maps via combinatorial Calabi flow for vertex scaling of polyhedral metrics on surfaces, which is an analogue of the combinatorial Yamabe flow introduced by Luo (Commun Contemp Math 6(5):765–780, 2004). To handle the singularies along the combinatorial Calabi flow, we do surgery on the flow by flipping. Using the discrete conformal theory established in Gu et al. (J Differ Geom 109(3):431–466, 2018; J Differ Geom 109(2):223–256, 2018), we prove that for any initial Euclidean or hyperbolic polyhedral metric on a closed surface, the combinatorial Calabi flow with surgery exists for all time and converges exponentially fast after finite number of surgeries. The convergence is independent of the combinatorial structure of the initial triangulation on the surface.

We consider the ensemble of adjacency matrices of Erd{\H o}s-R\'enyi random graphs, i.e.\ graphs on $N$ vertices where every edge is chosen independently and with probability $p \equiv p(N)$. We rescale the matrix so that its bulk eigenvalues are of order one. Under the assumption $p N \gg N^{2/3}$, we prove the universality of eigenvalue distributions both in the bulk and at the edge of the spectrum. More precisely, we prove (1) that the eigenvalue spacing of the Erd{\H o}s-R\'enyi graph in the bulk of the spectrum has the same distribution as that of the Gaussian orthogonal ensemble; and (2) that the second largest eigenvalue of the Erd{\H o}s-R\'enyi graph has the same distribution as the largest eigenvalue of the Gaussian orthogonal ensemble. As an application of our method, we prove the bulk universality of generalized Wigner matrices under the assumption that the matrix entries have at least $4 + \epsilon$ moments.

Let M be a compact Hamiltonian T−space, with finite fixed point set MT . An equivariant class is determined by its restriction to MT , and to each fixed point p ∈ MT and generic component of the moment map, there corresponds a canonical class τp. For a special class of Hamiltonian T−spaces, the value τp,q of τp at a fixed point q can be determined through an iterated interpolation procedure, and we obtained a formula for τp,q as a sum over ascending chains from p to q. In general the number of such chains is huge, and the main result of this paper is a procedure to reduce the number of relevant chains, through a systematic degeneration of the interpolation direction. The resulting formula for τp,q resembles, via the localization formula, an integral over a space of chains, and we prove that, for complex Grassmannians, τp,q can indeed be expressed as the integral of an equivariant form over a smooth Schubert variety.

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