We propose a novel method to apply Teichmller space theory to study the signature of a family of nonintersecting closed 3D curves on a general genus zero closed surface. Our algorithm provides an efficient method to encode both global surface and local contour shape information. The signatureTeichmller shape descriptoris computed by surface Ricci flow method, which is equivalent to solving an elliptic partial differential equation on surfaces and is numerically stable. We propose to apply the new signature to analyze abnormalities in brain cortical morphometry. Experimental results with 3D MRI data from Alzheimers disease neuroimaging initiative (ADNI) dataset [152 healthy control subjects versus 169 Alzheimers disease (AD) patients] demonstrate the effectiveness of our method and illustrate its potential as a novel surface-based cortical morphometry measurement in AD research.

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Let Δ be the Laplace-Beltrami operator on an$n$dimensional complete$C$^{∞}manifold$M$In this paper we establish an estimate of$e$^{$tΔ$}$(dμ)$valid for all$t$>0 where$dμ$is a locally uniformly α dimensional measure on$M$0≤α≤$n$The result is used to study the mapping properties of ($I$-$t$Δ)^{-β}considered as an operator from$L$^{$p$}$(M dμ)$to$L$^{$p$}$(M dx)$where$dx$is the Riemannian measure on$M β>(n−α)/2p′ 1/p+1/p′=1 1≤p≤∞$