Zika virus (ZIKV) is a mosquito-borne flavivirus. It was first isolated from Uganda in 1947 and has become an emergent event since 2007. However, because of the inconsistency of alignment methods, the evolution of ZIKV remains poorly understood. In this study, we first use the complete protein and an alignment-free method to build a phylogenetic tree of 87 Zika strains in which Asian, East African, and West African lineages are characterized. We also use the NS5 protein to construct the genetic relationship among 44 Zika strains. For the first time, these strains are divided into two clades: African 1 and African 2. This result suggests that ZIKV originates from Africa, then spread to Asia, Pacific islands, and throughout the Americas. We also perform the phylogeny analysis for 53 viruses in genus Flavivirus to which ZIKV belongs using complete proteins. Our conclusion is consistent with the classification by the hosts and transmission vectors.

We consider Hermitian and symmetric random band matrices $H = (h_{xy})$ in $d \geq 1$ dimensions. The matrix entries $h_{xy}$, indexed by $x,y \in (\bZ/L\bZ)^d$, are independent, centred random variables with variances $s_{xy} = \E |h_{xy}|^2$. We assume that $s_{xy}$ is negligible if $|x-y|$ exceeds the band width $W$. In one dimension we prove that the eigenvectors of $H$ are delocalized if $W\gg L^{4/5}$. We also show that the magnitude of the matrix entries $\abs{G_{xy}}^2$ of the resolvent $G=G(z)=(H-z)^{-1}$ is self-averaging and we compute $\E \abs{G_{xy}}^2$. We show that, as $L\to\infty$ and $W\gg L^{4/5}$, the behaviour of $\E |G_{xy}|^2$ is governed by a diffusion operator whose diffusion constant we compute. Similar results are obtained in higher dimensions.

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