Let Ω⊂ℝ^{$n$}be an arbitrary open set. We characterize the space$W$^{1,1}_{loc}(Ω) using variants of the classical area and coarea formulas. We use these characterizations to obtain a norm approximation and trace theorems for functions in the space$W$^{1,1}(ℝ^{$n$}).

A comprehensive description of human genomes is essential for understanding human evolution and relationships between modern populations. However, most published literature focuses on local alignment comparison of several genes rather than the complete evolutionary record of individual genomes. Combining with data from the 1,000 Genomes Project, we successfully reconstructed 2,504 individual genomes and propose Divided Natural Vector method to analyze the distribution of nucleotides in the genomes. Comparisons based on autosomes, sex chromosomes and mitochondrial genomes reveal the genetic relationships between populations, and different inheritance pattern leads to different phylogenetic results. Results based on mitochondrial genomes confirm the “out-of-Africa” hypothesis and assert that humans, at least females, most likely originated in eastern Africa. The reconstructed genomes are stored on our server and can be further used for any genome-scale analysis of humans (http://yaulab.math.tsinghua.edu.cn/2022_1000genomesprojectdata/). This project provides the complete genomes of thousands of individuals and lays the groundwork for genome-level analyses of the genetic relationships between populations and the origin of humans.

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Distinct quantum vacua of topologically ordered states can be tunneled into each other, not by local operators, but via extended operators. The possible applications include condensed matter and quantum cosmology. We present a straightforward approach to calculate the partition function on various manifolds and ground state degeneracy (GSD), mainly based on continuum/cochain Topological Quantum Field Theories (TQFT), in any dimension. This information can be related to the counting of extended operators of bosonic/fermionic TQFT. On the lattice scale, anyonic particles/strings live at the ends of line/surface operators. Certain systems in different dimensions are related to each other through dimensional reduction schemes, analogous to decategorification. We consider situations where a TQFT lives on (1) a closed spacetime or (2) a spacetime with boundary, such that both the bulk and boundary are fully-gapped and long-range entangled (LRE). Anyonic excitations can be deconfined on the boundary. We introduce new exotic topological interfaces on which neither particle nor string excitations alone condensed, but only fuzzy-composite objects of extended operators can end (e.g. a string-like fuzzy-composite object formed by a set of particles can end on a special 2+1D boundary of 3+1D bulk). We explore the relations between group extension constructions and partially breaking constructions (e.g. 0-form/higher-form/“composite” breaking) of topological boundaries, after gauging. We comment on the implications of entanglement entropy for some of such LRE systems.

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