In the presence of vacuum, the physical entropy for polytropic gases behaves singularly and it is thus a challenge to study its dynamics. It is shown in this paper that the boundedness of the entropy can be propagated up to any finite time provided that the initial vacuum presents only at far fields with sufficiently slow decay of the initial density. More precisely, for the Cauchy problem of the onedimensional heat conductive compressible Navier--Stokes equations, the global well-posedness of strong solutions and uniform boundedness of the corresponding entropy are established, as long as the initial density vanishes only at far fields with a rate no more than $O(\frac{1}{x^2})$. The main tools of proving the uniform boundedness of the entropy are some singularly weighted energy estimates carefully designed for the heat conductive compressible Navier--Stokes equations and an elaborate De Giorgi type iteration technique for some classes of degenerate parabolic equations. The De Giorgi type iterations are carried out to different equations in establishing the lower and upper bounds of the entropy.

The convergence to steady state solutions of the Euler equations for weighted compact nonlinear schemes (WCNS) [Deng X. and Zhang H. (2000), J. Comput. Phys. 165, 22-44 and Zhang S., Jiang S and Shu C.-W. (2008), J. Comput. Phys. 227, 7294-7321] is studied through numerical tests. Like most other shock capturing schemes, WCNS also suffers from the problem that the residue can not settle down to machine zero for the computation of the steady state solution which contains shock waves but hangs at the truncation error level. In this paper, the techniques studied in [Zhang S. and Shu. C.-W. (2007), J. Sci. Comput. 31, 273-305 and Zhang S., Jiang S and Shu. C.-W. (2011), J. Sci. Comput. 47, 216-238], to improve the convergence to steady state solutions for WENO schemes, are generalized to the WCNS. Detailed numerical studies in one and two dimensional cases are performed. Numerical tests demonstrate the effectiveness of these techniques when applied to WCNS. The residue of various order WCNS can settle down to machine zero for typical cases while the small post-shock oscillations can be removed.

Over time, a population acquires neutral genetic substitutions as a consequence of random drift. A famous result in population genetics asserts that the rate, K, at which these substitutions accumulate in the population coincides with the mutation rate, u, at which they arise in individuals: K = u. This identity enables genetic sequence data to be used as a “molecular clock” to estimate the timing of evolutionary events. While the molecular clock is known to be perturbed by selection, it is thought that K = u holds very generally for neutral evolution. Here we show that asymmetric spatial population structure can alter the molecular clock rate for neutral mutations, leading to either K<u or K>u. Our results apply to a general class of haploid, asexually reproducing, spatially structured populations. Deviations from K = u occur because mutations arise unequally at different sites and have different probabilities of fixation depending on where they arise. If birth rates are uniform across sites, then K
u. In general, K can take any value between 0 and Nu. Our model can be applied to a variety of population structures. In one example, we investigate the accumulation of genetic mutations in the small intestine. In another application, we analyze over 900 Twitter networks to study the effect of network topology on the fixation of neutral innovations in social evolution.

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