Suppose we lhave n observationis ftom Y= X+ c, where e is nieasuremiienit error with kiowin distributioni, and the denesity f of X is uniknowii withi thte nloln-paraniietric conistrainit

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In this paper, we prove a conjecture of Kottwitz and Rapoport on a union of (generalized) affine Deligne-Lusztig varieties $X(\mu, b)_J$ for a $p$-adic group $G$ and its parahoric subgroup $P_J$. We show that $X(\mu, b)_J \neq \emptyset$ if and only if the group-theoretic version of Mazur's inequality is satisfied. In the process, we obtain a generalization of Grothendieck's conjecture on the closure relation of $\s$-conjugacy classes of a twisted loop group.

Kaimanovich (2003) [9] introduced the concept of augmented tree on the symbolic space of a selfsimilar set. It is hyperbolic in the sense of Gromov, and it was shown by Lau and Wang (2009) [12] that under the open set condition, a self-similar set can be identified with the hyperbolic boundary of the tree. In the paper, we investigate in detail a class of simple augmented trees and the Lipschitz equivalence of such trees. The main purpose is to use this to study the Lipschitz equivalence problem of the totally disconnected self-similar sets which has been undergoing some extensive development recently.

There is an unmet medical need to identify neuroimaging biomarkers that is able to accurately diagnose and monitor Alzheimer's disease (AD) at very early stages and assess the response to AD-modifying therapies. To a certain extent, volumetric and functional magnetic resonance imaging (fMRI) studies can detect changes in structure, cerebral blood flow and blood oxygenation that are able to distinguish AD and mild cognitive impairment (MCI) subjects from normal controls. However, it has been challenging to use fully automated MRI analytic methods to identify potential AD neuroimaging biomarkers. We have thus proposed a method based on independent component analysis (ICA), for studying potential AD-related MR image features, coupled with the use of support vector machine (SVM) for classifying scans into categories of AD, MCI, and normal control (NC) subjects. The MRI data were selected from Open Access Series of Imaging Studies (OASIS) and the Alzheimer's Disease Neuroimaging Initiative (ADNI) databases. The experimental results showed that our ICA-based method can differentiate AD and MCI subjects from normal controls, although further methodological improvement in the analytic method and inclusion of additional variables may be required for optimal classification.