Let<i>M</i> be a space-time whose local mass density is non-negative everywhere. Then we prove that the total mass of<i>M</i> as viewed from spatial infinity (the ADM mass) must be positive unless<i>M</i> is the flat Minkowski space-time. (So far we are making the reasonable assumption of the existence of a maximal spacelike hypersurface. We will treat this topic separately.) We can generalize our result to admit wormholes in the initial-data set. In fact, we show that the total mass associated with each asymptotic regime is non-negative with equality only if the space-time is flat.