Alzheimer's disease (AD) is a no-cure disease that has been frustrating the scientists for many years. Analyzing the disease has become an important but challenging research topic. The shape analysis of the sub-cortical structure of AD patients has been commonly used to understand this disease. In this paper, we assess the feasibility of using shape information on the hippocampal (HP) surfaces to detect some sub-structural changes in AD patients. We propose a quasi-conformal statistical shape analysis model, which allows us to study local regional geometric changes in the HPs amongst normal control (NC) and AD groups. A shape index defined by the quasi-conformality and surface curvatures is used to characterize region-specific shape variations of the HP surfaces. Feature vectors can be extracted for each HPs, with which a classification model can be built using machine learning methods to classify HPs into NC and AD subjects. Experiments have been carried out on 99 normal controls and 41 patients with AD. Results demonstrate that the proposed quasi-conformal based model is effective for classifying HPs into NC and AD groups with high classification accuracy (with highest overall classification accuracy reaching 87.86% in a leave-one-out experiment using the whole dataset).

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In this work we investigate the decorated domain wall construction in bosonic group-cohomology symmetry-protected topological (SPT) phases and related quantum anomalies in bosonic topological phases. We first show that a general decorated domain wall construction can be described mathematically as an Atiyah-Hirzebruch spectral sequence, where the terms on the E2 page correspond to decorations by lower-dimensional SPT states at domain wall junctions. For bosonic group-cohomology SPT phases, the spectral sequence becomes the Lyndon-Hochschild-Serre (LHS) spectral sequence for ordinary group cohomology. We then discuss the physical interpretations of the differentials in the spectral sequence, particularly in the context of anomalous SPT phases and symmetry-enriched gauge theories. As the main technical result, we obtain a full description of the LHS spectral sequence concretely at the cochain level. The explicit formulae are then applied to explain Lieb-Schultz-Mattis theorems for SPT phases, and also derive a new LSM theorem for easy-plane spin model in a π flux lattice. We also revisit the classifications of symmetry-enriched 2D and 3D Abelian gauge theories using our results.

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