We give a description of the completion of the manifold of all smooth Riemannian metrics on a fixed smooth, closed, finitedimensional, orientable manifold with respect to a natural metric called the L2 metric. The primary motivation for studying this problem comes from Teichm¨uller theory, where similar considerations lead to a completion of the well-known Weil-Petersson metric. We give an application of the main theorem to the completions of Teichm¨uller space with respect to a class of metrics that generalize the Weil-Petersson metric.

Gene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established. In the MAQC-II project, 36 independent teams analyzed six microarray data sets to generate predictive models for classifying a sample with respect to one of 13 endpoints indicative of lung or liver toxicity in rodents, or of breast cancer, multiple myeloma or neuroblastoma in humans. In total,> 30,000 models were built using many combinations of analytical methods. The teams generated predictive models without knowing the biological meaning of some of the endpoints and, to mimic clinical reality, tested the models on data that had not been used for training. We found that model performance depended largely on the endpoint and team proficiency and that different approaches generated models of similar performance. The conclusions and

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In this article, we define a “ recursive local” algorithm in order to construct two reccurent numerical sequences of positive prime numbers (𝑈2𝑛) and (𝑉2𝑛), ((𝑈2𝑛) function of (𝑉2𝑛)), such that for any integer n≥ 2, their sum is 2n. To build these , we use a third sequence of prime numbers (𝑊2𝑛) defined for any integer n≥ 3 by : 𝑊2𝑛 = Sup(p∈IP : p ≤ 2n-3), where IP is the infinite set of positive prime numbers. The Goldbach conjecture has been verified for all even integers 2n between 4 and 4.1018. . In the Table of Goldbach sequence terms given in paragraph § 10, we reach values of the order of 2n= 101000 . Thus, thanks to this algorithm of “ascent and descent”, we can validate the strong Euler-Goldbach conjecture.

Suppose that$X$is a vector field on a manifold$M$whose flow, exp$tX$, exists for all time. If μ is a measure on$M$for which the induced measures$μ$_{$t$}≡(exp$tX$)_{*}$μ$are absolutely continuous with respect to μ, it is of interest to establish bounds on the$L$^{$p$}(μ) norm of the Radon-Nikodym derivative$dμ$_{$t$}/$dμ$. We establish such bounds in terms of the divergence of the vector field$X$. We then specilize$M$to be a complex manifold and derive reverse hypercontractivity bounds and reverse logarithmic Sololev inequalities in some holomorphic function spaces. We give examples on$C$^{m}and on the Riemann surface for$z$^{1/$n$}.