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With sharp increasing in biological sequences, the traditional sequence alignment methods become unsuitable and infeasible. It motivates a surge of fast alignment-free techniques for sequence analysis. Among these methods, many sorts of feature vector methods are established and applied to reconstruction of species phylogeny. The vectors basically consist of some typical numerical features for certain biological problems. The features may come from the primary sequences, secondary or three dimensional structures of macromolecules. In this study, we propose a novel numerical vector based on only primary sequences of organism to build their phylogeny. Three chemical and physical properties of primary sequences: purine, pyrimidine and keto are also incorporated to the vector. Using each property, we convert the nucleotide sequence into a new sequence consisting of only two kinds of letters. Therefore, three sequences are constructed according to the three properties. For each letter of each sequence we calculate the number of the letter, the average position of the letter and the variation of the position of the letter appearing in the sequence. Tested on several datasets related to mammals, viruses and bacteria, this new tool is fast in speed and accurate for inferring the phylogeny of organisms.

In this article we propose a geometric description of Arthur packets for p-adic groups using vanishing cycles of perverse sheaves. Our approach is inspired by the 1992 book by Adams, Barbasch and Vogan on the Langlands classification of admissible representations of real groups and follows the direction indicated by Vogan in his 1993 paper on the Langlands correspondence. Using vanishing cycles, we introduce and study a functor from the category of equivariant perverse sheaves on the moduli space of certain Langlands parameters to local systems on the regular part of the conormal bundle for this variety. In this article we establish the main properties of this functor and show that it plays the role of microlocalization in the work of Adams, Barbasch and Vogan. We use this to define ABV-packets for pure rational forms of p-adic groups and propose a geometric description of the transfer coefficients that appear in Arthur's main local result in the endoscopic classification of representations. This article includes conjectures modelled on Vogan's work, especially the prediction that Arthur packets are ABV-packets for p-adic groups. We gather evidence for these conjectures by verifying them in numerous examples.

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