We study knots in 3d Chern-Simons theory with complex gauge group SL(N,C), in the context of its relation with 3d N=2 theory (the so-called 3d-3d correspondence). The defect has either co-dimension 2 or co-dimension 4 inside the 6d (2,0) theory, which is compactified on a 3-manifold M^. We identify such defects in various corners of the 3d-3d correspondence, namely in 3d SL(N,C) Chern-Simons theory, in 3d N=2 theory, in 5d N=2 super Yang-Mills theory, and in the M-theory holographic dual. We can make quantitative checks of the 3d-3d correspondence by computing partition functions at each of these theories. This Letter is a companion to a longer paper, which contains more details and more results.