The study of 2D shapes is a central problem in the field of computer vision. In 2D shape analysis, classification and recognition of objects from their observed silhouettes are extremely crucial and yet difficult. It usually involves an efficient representation of 2D shape space with natural metric, so that its mathematical structure can be used for further analysis. Although significant progress has been made for the study of 2D simply-connected shapes, very few works have been done on the study of 2D objects with arbitrary topologies. In this work, we propose a representation of general 2D domains with arbitrary topologies using conformal geometry. A natural metric can be defined on the proposed representation space, which gives a metric to measure dissimilarities between objects. The main idea is to map the exterior and interior of the domain conformally to unit disks and circle domains, using holomorphic 1-forms. A set of diffeomorphisms from the unit circle S^1 to itself can be obtained, which together with the conformal modules are used to define the shape signature. We prove mathematically that our proposed signature uniquely represents shapes with arbitrary topologies. We also introduce a reconstruction algorithm to obtain shapes from their signatures. This completes our framework and allows us to move back and forth between shapes and signatures. Experiments show the efficacy of our proposed algorithm as a stable shape representation scheme.

There is an unmet medical need to identify neuroimaging biomarkers that is able to accurately diagnose and monitor Alzheimer's disease (AD) at very early stages and assess the response to AD-modifying therapies. To a certain extent, volumetric and functional magnetic resonance imaging (fMRI) studies can detect changes in structure, cerebral blood flow and blood oxygenation that are able to distinguish AD and mild cognitive impairment (MCI) subjects from normal controls. However, it has been challenging to use fully automated MRI analytic methods to identify potential AD neuroimaging biomarkers. We have thus proposed a method based on independent component analysis (ICA), for studying potential AD-related MR image features, coupled with the use of support vector machine (SVM) for classifying scans into categories of AD, MCI, and normal control (NC) subjects. The MRI data were selected from Open Access Series of Imaging Studies (OASIS) and the Alzheimer's Disease Neuroimaging Initiative (ADNI) databases. The experimental results showed that our ICA-based method can differentiate AD and MCI subjects from normal controls, although further methodological improvement in the analytic method and inclusion of additional variables may be required for optimal classification.

This paper proposes a novel algorithm to extract feature landmarks on the vestibular system (VS), for the analysis of Adolescent Idiopathic Scoliosis (AIS) disease. AIS is a 3-D spinal deformity commonly occurred in adolescent girls with unclear etiology. One popular hypothesis was suggested to be the structural changes in the VS that induce the disturbed balance perception, and further cause the spinal deformity. The morphometry of VS to study the geometric differences between the healthy and AIS groups is of utmost importance. However, the VS is a genus-3 structure situated in the inner ear. The high-genus topology of the surface poses great challenge for shape analysis. In this work, we present a new method to compute exact geodesic loops on the VS. The resultant geodesic loops are in Euclidean metric, thus characterizing the intrinsic geometric properties of the VS based on the real background geometry. This leads to more accurate results than existing methods, such as the hyperbolic Ricci flow method. Furthermore, our method is fully automatic and highly efficient, e.g., one order of magnitude faster than. We applied our algorithm to the VS of normal and AIS subjects. The promising experimental results demonstrate the efficacy of our method and reveal more statistically significant shape difference in the VS between right-thoracic AIS and normal subjects.

In this paper, we propose novel algorithms for inpainting and refinement of diffeomorphisms. We first represent a diffeomorphism by its Beltrami coefficient. Then it is possible to refine and inpaint the diffeomorphism by processing this Beltrami coefficient. With the inpainted/refined Beltrami coefficient, we construct a new diffeomorphism using the exact Beltrami holomorphic flow algorithm proposed in this paper. We apply our algorithms on several practical applications, which include the inpainting of a highly distorted diffeomorphism, the inpainting of image sequences of deforming shapes, the super-resolution of diffeomorphisms and the global parameterization of cortical surfaces by combining local parameterizations. Experiments show that our algorithm can solve these problems with natural and smooth results. We demonstrate how our proposed method can be widely applied in areas from texture mapping to video processing, and from computer graphics to medical imaging.

In shape analysis, finding an optimal 1-1 correspondence between 3D surfaces within a large class of admissible bijective mappings is of great importance. Such a process is called surface registration. The difficulty lies in the fact that the space of all surface diffeomorphisms is a complicated functional space, making it challenging to exhaustively search for the best mapping. To tackle this problem, we propose a simple representation of bijective surface maps using Beltrami coefficients (BCs)—complex-valued functions defined on surfaces with supremum norm less than 1. Fixing any 3 points on a pair of surfaces, there is a 1-1 correspondence between the set of surface diffeomorphisms between them and the set of BCs. Hence, every bijective surface map may be represented by a unique BC. Conversely, given a BC, we can reconstruct the unique surface map associated with it using the Beltrami Holomorphic flow (BHF) method. Using BCs to represent surface maps is advantageous because it is a much simpler functional space, which captures many essential features of a surface map. By adjusting BCs, we equivalently adjust surface diffeomorphisms to obtain the optimal map with desired properties. More specifically, BHF gives us the variation of the associated map under the variation of BC. Using this, a variational problem over the space of surface diffeomorphisms can be easily reformulated into a variational problem over the space of BCs. This makes the minimization procedure much easier. More importantly, the diffeomorphic property is always preserved. We test our method on synthetic examples and real medical applications. Experimental results demonstrate the effectiveness of our proposed algorithm for surface registration.