We propose a new method to obtain landmark-matching transformations between n-dimensional Euclidean spaces with large deformations. Given a set of feature correspondences, our algorithm searches for an optimal folding-free mapping that satisfies the prescribed landmark constraints. The standard conformality distortion defined for mappings between 2-dimensional spaces is first generalized to the n-dimensional conformality distortion K(f) for a mapping f between n-dimensional Euclidean spaces (n≥3). We then propose a variational model involving K(f) to tackle the landmark-matching problem in higher dimensional spaces. The generalized conformality term K(f) enforces the bijectivity of the optimized mapping and minimizes its local geometric distortions even with large deformations. Another challenge is the high computational cost of the proposed model. To tackle this, we have also proposed a numerical method to solve the optimization problem more efficiently. Alternating direction method with multiplier (ADMM) is applied to split the optimization problem into two subproblems. Preconditioned conjugate gradient method with multi-grid preconditioner is applied to solve one of the sub-problems, while a fixed-point iteration is proposed to solve another subproblem. Experiments have been carried out on both synthetic examples and lung CT images to compute the diffeomorphic landmark-matching transformation with different landmark constraints. Results show the efficacy of our proposed model to obtain a folding-free landmark-matching transformation between n-dimensional spaces with large deformations.

A fresh framework for mesh optimization, the Filtered Hooke's Optimization, is proposed. With the notion of the elasticity theory, the Hooke's Optimization is developed by modifying the Hooke's law, in which an elastic force is simulated on the edges of a mesh so that adjacent vertices are either attracted to each other or repelled from each other, so as to regularize the mesh in terms of triangulation. A normal torque force is acted on vertices to guarantee smoothness of the surface. In addition, a filtering scheme, called the Newtonian Filtering, is proposed as a supplementary tool for the proposed Hooke's Optimization to preserve the geometry of the mesh. Numerical simulations on meshes with different geometry indicate an impressive performance of our proposed framework to significantly improve the mesh triangulation without noteworthy distortions of the mesh geometry.

This paper proposes a novel approach for extracting two intrinsic feature curves on hippocampal (HC) surfaces. The hippocampus is a key target of study in medical imaging, as it degenerates in conditions such as epilepsy and Alzheimer's disease (AD), but its structure is complex. To facilitate HC morphometry, we generate two intrinsic feature curves that describe their global geometries. For example, the separation of them captures thickness changes in HC surfaces, which can be used to effectively measure HC atrophy found in patients with AD. They also separate HC surfaces into upper and lower surface patches where intrinsic shape analysis using conformal modules can be carried out. Based on these curves, we further propose a parameterization of HC surfaces called the eigen-harmonic parameterization (EHP). EHP maps each HC surface onto a parameter domain and imposes longitudinal and azimuthal coordinates on each surface, which follow the gradient and level sets of its first nontrivial Laplace-Beltrami eigenfunction, respectively. Each tubular domain is constructed according to the geometry of an individual HC surface. This gives a parameter domain with much less geometric distortion compared to spherical parameterization. With EHP, all HC surfaces are automatically registered with intrinsic feature curves preserved and geometric distortions minimized. This allows shape analysis on any number of HC surfaces to be performed consistently. We studied geometric changes over time in 138 HC surfaces of patients with AD and normal subjects scanned at two different times. We successfully located areas with significantly different shape changes over time between the two groups.

We develop a general approach that uses holomorphic 1-forms to parameterize anatomical surfaces with complex (possibly branching) topology. Rather than evolve the surface geometry to a plane or sphere, we instead use the fact that all orientable surfaces are Riemann surfaces and admit conformal structures, which induce special curvilinear coordinate systems on the surfaces. Based on Riemann surface structure, we can then canonically partition the surface into patches. Each of these patches can be conformally mapped to a parallelogram. The resulting surface subdivision and the parameterizations of the components are intrinsic and stable. To illustrate the technique, we computed conformal structures for several types of anatomical surfaces in MRI scans of the brain, including the cortex, hippocampus, and lateral ventricles. We found that the resulting parameterizations were consistent across

We propose a method to map a multiply connected bounded planar region conformally to a bounded region with circular boundaries. The norm of the derivative of such a conformal map satisfies the Laplace equation with a nonlinear Neumann type boundary condition. We analyze the singular behavior at corners of the boundary and separate the major singular part. The remaining smooth part solves a variational problem which is easy to discretize. We use a finite element method and a gradient descent method to find an approximate solution. The conformal map is then constructed from this norm function. We tested our algorithm on a polygonal region and a curvilinear smooth region.