Registration, which aims to find an optimal one-to-one correspondence between different data, is an important problem in various fields. This problem is especially challenging when large deformations occur. In this paper, we present a novel algorithm to obtain diffeomorphic image or surface registrations with large deformations via quasi-conformal maps. The basic idea is to minimize an energy functional involving a Beltrami coefficient term, which measures the distortion of the quasi-conformal map. The Beltrami coefficient effectively controls the bijectivity and smoothness of the registration, even with very large deformations. Using the proposed algorithm, landmark-based registration between images or surfaces can be effectively computed. The obtained registration is guaranteed to be diffeomorphic (1-1 and onto), even with a large deformation or large number of landmark constraints. The proposed algorithm can also be combined with matching intensity (such as image intensity or surface curvature) to improve the accuracy of the registration. Experiments have been carried out on both synthetic and real data. Results demonstrate the efficacy of the proposed algorithm to obtain diffeomorphic registration between images or surfaces.

Adolescent Idiopathic Scoliosis (AIS) characterized by the 3D spine deformity affects about 4% schoolchildren worldwide. Several studies have demonstrated the malfunctioning of postural balance, proprioception, and equilibrium control in patients with AIS. Since these functions are closely related to structures in and around the brainstem, the morphometry of the brainstem surface is of utmost importance. In this paper, we propose an effective method to accurately compute the registration between brainstem surfaces. Four consistent features, which describe the global geometry of the brainstem, are automatically extracted to guide the surface registration. Using the discrete Ricci flow method, brainstem surfaces are parameterized conformally onto the quadrilaterally-faced hexahedron, through which the brainstem registration can be obtained. Our registration algorithm can guarantee the exact landmark correspondence between brainstem surfaces. With the obtained registration, a shape energy can be defined to measure the local shape difference between different brainstem surfaces. We have tested our algorithms on 30 real brainstem surfaces extracted from MRIs of 15 normal subjects and 15 AIS patients. Experimental results show the efficacy of the proposed algorithm to register brainstem surfaces, which matches landmark features consistently. The computed registration can be used for the morphometry of brainstems.

We propose a new method to obtain landmark-matching transformations between n-dimensional Euclidean spaces with large deformations. Given a set of feature correspondences, our algorithm searches for an optimal folding-free mapping that satisfies the prescribed landmark constraints. The standard conformality distortion defined for mappings between 2-dimensional spaces is first generalized to the n-dimensional conformality distortion K(f) for a mapping f between n-dimensional Euclidean spaces (n≥3). We then propose a variational model involving K(f) to tackle the landmark-matching problem in higher dimensional spaces. The generalized conformality term K(f) enforces the bijectivity of the optimized mapping and minimizes its local geometric distortions even with large deformations. Another challenge is the high computational cost of the proposed model. To tackle this, we have also proposed a numerical method to solve the optimization problem more efficiently. Alternating direction method with multiplier (ADMM) is applied to split the optimization problem into two subproblems. Preconditioned conjugate gradient method with multi-grid preconditioner is applied to solve one of the sub-problems, while a fixed-point iteration is proposed to solve another subproblem. Experiments have been carried out on both synthetic examples and lung CT images to compute the diffeomorphic landmark-matching transformation with different landmark constraints. Results show the efficacy of our proposed model to obtain a folding-free landmark-matching transformation between n-dimensional spaces with large deformations.

This paper proposes a novel algorithm to extract feature landmarks on the vestibular system (VS), for the analysis of Adolescent Idiopathic Scoliosis (AIS) disease. AIS is a 3-D spinal deformity commonly occurred in adolescent girls with unclear etiology. One popular hypothesis was suggested to be the structural changes in the VS that induce the disturbed balance perception, and further cause the spinal deformity. The morphometry of VS to study the geometric differences between the healthy and AIS groups is of utmost importance. However, the VS is a genus-3 structure situated in the inner ear. The high-genus topology of the surface poses great challenge for shape analysis. In this work, we present a new method to compute exact geodesic loops on the VS. The resultant geodesic loops are in Euclidean metric, thus characterizing the intrinsic geometric properties of the VS based on the real background geometry. This leads to more accurate results than existing methods, such as the hyperbolic Ricci flow method. Furthermore, our method is fully automatic and highly efficient, e.g., one order of magnitude faster than. We applied our algorithm to the VS of normal and AIS subjects. The promising experimental results demonstrate the efficacy of our method and reveal more statistically significant shape difference in the VS between right-thoracic AIS and normal subjects.

We develop a general approach that uses holomorphic 1-forms to parameterize anatomical surfaces with complex (possibly branching) topology. Rather than evolve the surface geometry to a plane or sphere, we instead use the fact that all orientable surfaces are Riemann surfaces and admit conformal structures, which induce special curvilinear coordinate systems on the surfaces. Based on Riemann surface structure, we can then canonically partition the surface into patches. Each of these patches can be conformally mapped to a parallelogram. The resulting surface subdivision and the parameterizations of the components are intrinsic and stable. To illustrate the technique, we computed conformal structures for several types of anatomical surfaces in MRI scans of the brain, including the cortex, hippocampus, and lateral ventricles. We found that the resulting parameterizations were consistent across