In this paper, we generalize the anomaly cancellation formulas given by Alvarez-Gaum and Witten (1983), Liu (1995) and Han and Zhang (2004)[1],[2],[7] to the cases where an auxiliary bundle W and a complex line bundle are involved with no conditions on the first Pontryagin forms being assumed.

Vector cross product structures on manifolds include symplectic, volume, G2- and Spin(7)-structures. We show that the knot spaces of such manifolds have natural symplectic structures, and relate instantons and branes in these manifolds to holomorphic disks and Lagrangian submanifolds in their knot spaces. For the complex case, the holomorphic volume form on a Calabi–Yau manifold defines a complex vector cross product structure. We show that its isotropic knot space admits a natural holomorphic symplectic structure.We also relate the Calabi–Yau geometry of the manifold to the holomorphic symplectic geometry of its isotropic knot space.

By studying modular invariance properties of some characteristic forms, we prove some new anomaly cancellation formulas which generalize the Han-Zhang and Han-Liu-Zhang anomaly cancellation formulas

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