Modeling cell differentiation from omics data is an essential problem in systems biology research. Although many algorithms have been established to analyze scRNA-seq data, approaches to infer the pseudo-time of cells or quantify their potency have not yet been satisfactorily solved. Here, we propose the Landscape of Differentiation Dynamics (LDD) method, which calculates cell potentials and constructs their differentiation landscape by a continuous birth-death process from scRNA-seq data. From the viewpoint of stochastic dynamics, we exploited the features of the differentiation process and quantified the differentiation landscape based on the source-sink diffusion process. In comparison with other scRNA-seq methods in seven benchmark datasets, we found that LDD could accurately and efficiently build the evolution tree of cells with pseudo-time, in particular quantifying their differentiation landscape in terms of potency. This study provides not only a computational tool to quantify cell potency or the Waddington potential landscape based on scRNA-seq data, but also novel insights to understand the cell differentiation process from a dynamic perspective.

Firstly, a formal correspondence is established between the CamassaHolm (CH) equation and a two-component modified CH (or called SQQ) equation according to the method of <i>moment modification</i> for multipeakon formulae. Secondly, based on the generalized nonisospectral CH equation in Chang et al. (2014) [14] and the interlacing multipeakons of the two-component modified CH equation in Chang et al. (2016) [15], we propose a new generalized two-component modified CH equation with two parameters, which possesses a nonisospectral Lax pair. The proposed equation still admits multipeakon solutions of explicit and closed form. Sufficient conditions for global existence of solutions are given and two concrete examples with certain interesting phenomenon are presented. Last of all, as a by-product, a generalized nonisospectral modified CH equation is deduced, together with its Lax pair.

Motivated by reformulating Furstenberg's $\times p,\times q$ conjecture via representations of a crossed product $C^*$-algebra, we show that in a discrete $C^*$-dynamical system $(A,\Gamma)$, the space of (ergodic) $\Gamma$-invariant states on $A$ is homeomorphic to a subspace of (pure) state space of $A\rtimes\Gamma$. Various applications of this in topological dynamical systems and representation theory are obtained. In particular, we prove that the classification of ergodic $\Gamma$-invariant regular Borel probability measures on a compact Hausdorff space $X$ is equivalent to the classification a special type of irreducible representations of $C(X)\rtimes \Gamma$.

We show that theMöbius function is disjoint to every analytic skew product dynamical system on T2 over a rotation of the circle.

In this Letter we propose that for Lax integrable nonlinear partial differential equations the natural concept of weak solutions is implied by the compatibility condition for the respective distributional Lax pairs. We illustrate our proposal by comparing two concepts of weak solutions of the modified Camassa-Holm equation pointing out that in the <i>peakon</i> sector (a family of non-smooth solitons) only one of them, namely the one obtained from the distributional compatibility condition, supports the time invariance of the Sobolev <i>H</i>¹ norm.