We prove the dynamical Mordell-Lang conjecture for birational polynomial morphisms on A^2.

We introduce canonical antisymmetric quasiconformal maps, which minimize the quasiconformality constant among maps sending the unit circle to a given quasicircle. As an application we prove Astala’s conjecture that the Hausdorff dimension of a$k$-quasicircle is at most 1+$k$^{2}.

Modeling cell differentiation from omics data is an essential problem in systems biology research. Although many algorithms have been established to analyze scRNA-seq data, approaches to infer the pseudo-time of cells or quantify their potency have not yet been satisfactorily solved. Here, we propose the Landscape of Differentiation Dynamics (LDD) method, which calculates cell potentials and constructs their differentiation landscape by a continuous birth-death process from scRNA-seq data. From the viewpoint of stochastic dynamics, we exploited the features of the differentiation process and quantified the differentiation landscape based on the source-sink diffusion process. In comparison with other scRNA-seq methods in seven benchmark datasets, we found that LDD could accurately and efficiently build the evolution tree of cells with pseudo-time, in particular quantifying their differentiation landscape in terms of potency. This study provides not only a computational tool to quantify cell potency or the Waddington potential landscape based on scRNA-seq data, but also novel insights to understand the cell differentiation process from a dynamic perspective.

No abstract uploaded!

We examine the convergence in the Krylov–Bogolyubov averaging for nonlinear stochastic perturbations of linear PDEs with pure imaginary spectrum and show that if the involved effective equation is mixing, then the convergence is uniform in time.