We demonstrate how path integrals often used in problems of theoretical physics can be adapted to provide a machinery for performing Bayesian inference in function spaces. Such inference comes about naturally in the study of inverse problems of recovering continuous (infinite dimensional) coefficient functions from ordinary or partial differential equations, a problem which is typically ill-posed. Regularization of these problems using L2 function spaces (Tikhonov regularization) is equivalent to Bayesian probabilistic inference, using a Gaussian prior. The Bayesian interpretation of inverse problem regularization is useful since it allows one to quantify and characterize error and degree of precision in the solution of inverse problems, as well as examine assumptions made in solving the problem—namely whether the subjective choice of regularization is compatible with prior knowledge. Using path-integral formalism, Bayesian inference can be explored through various perturbative techniques, such as the semiclassical approximation, which we use in this manuscript. Perturbative path-integral approaches, while offering alternatives to computational approaches like Markov-Chain-Monte-Carlo (MCMC), also provide natural starting points for MCMC methods that can be used to refine approximations. In this manuscript, we illustrate a path-integral formulation for inverse problems and demonstrate it on an inverse problem in membrane biophysics as well as inverse problems in potential theories involving the Poisson equation.

In this paper we integrate semi-local patches and the weighted graph Laplacian into the framework of the low dimensional manifold model. This approach is much faster than the original LDMM algorithm. The number of iterations is typically reduced from 100 to 10 and the equations in each step are much easier to solve. This new approach is tested in image inpainting and denoising and the results are better than the original LDMM and competitive with state-of-the-art methods.

The moment-entropy inequality shows that a contin- uous random variable with given second moment and maximal Shannon entropy must be Gaussian. Stam’s inequality shows that a continuous random variable with given Fisher information and minimal Shannon entropy must also be Gaussian. The Crame ́r- Rao inequality is a direct consequence of these two inequalities. In this paper the inequalities above are extended to Renyi entropy, p-th moment, and generalized Fisher information. Gen- eralized Gaussian random densities are introduced and shown to be the extremal densities for the new inequalities. An extension of the Crame ́r–Rao inequality is derived as a consequence of these moment and Fisher information inequalities.

We present the application of a low dimensional manifold model (LDMM) on hyperspectral image (HSI) reconstruction. An important property of hyperspectral images is that the patch manifold, which is sampled by the three-dimensional blocks in the data cube, is generally of a low dimensional nature. This is a generalization of low-rank models in that hyperspectral images with nonlinear mixing terms can also fit in this framework. The point integral method (PIM) is used to solve a Laplace-Beltrami equation over a point cloud sampling the patch manifold in LDMM. Both numerical simulations and theoretical analysis show that the sample points constraint is correctly enforced by PIM. The framework is demonstrated by experiments on the reconstruction of both linear and nonlinear mixed hyperspectral images with a significant number of missing voxels and several entirely missing spectral bands.

We define the notion of a Ricci curvature lower bound for parametrized statistical models. Following the seminal ideas of Lott–Sturm–Villani, we define this notion based on the geodesic convexity of the Kullback–Leibler divergence in a Wasserstein statistical manifold, that is, a manifold of probability distributions endowed with a Wasserstein metric tensor structure. Within these definitions, which are based on Fisher information matrix and Wasserstein Christoffel symbols, the Ricci curvature is related to both, information geometry and Wasserstein geometry. These definitions allow us to formulate bounds on the convergence rate of Wasserstein gradient flows and information functional inequalities in parameter space. We discuss examples of Ricci curvature lower bounds and convergence rates in exponential family models.