No abstract uploaded!

Adult stem cells, which exist throughout the body, multiply by cell division to replenish dying cells or to promote regeneration to repair damaged tissues. To perform these functions during the lifetime of organs or tissues, stem cells need to maintain their populations in a faithful distribution of their epigenetic states, which are suscepti- ble to stochastic fluctuations during each cell division, unexpected injury, and potential genetic mutations that occur during many cell divisions. However, it remains unclear how the three processes of differentiation, proliferation, and apoptosis in regulating stem cells collectively manage these challenging tasks. Here, without consid- ering molecular details, we propose a genetic optimal control model for adult stem cell regeneration that includes the three fundamental processes, along with cell division and adaptation based on differ- ential fitnesses of phenotypes. In the model, stem cells with a distri- bution of epigenetic states are required to maximize expected performance after each cell division. We show that heteroge- neous proliferation that depends on the epigenetic states of stem cells can improve the maintenance of stem cell distributions to create balanced populations. A control strategy during each cell division leads to a feedback mechanism involving heterogeneous proliferation that can accelerate regeneration with less fluctuation in the stem cell population. When mutation is allowed, apoptosis evolves to maximize the performance during homeostasis after multiple cell divisions. The overall results highlight the importance of cross-talk between genetic and epigenetic regulation and the performance objectives during homeostasis in shaping a desirable heterogeneous distribution of stem cells in epigenetic states.

This paper studies the problem of finding best rank-1 approximations for both symmetric and nonsymmetric tensors. For symmetric tensors, this is equivalent to optimizing homogeneous polynomials over unit spheres; for nonsymmetric tensors, this is equivalent to optimizing multiquadratic forms over multispheres. We propose semidefinite relaxations, based on sum of squares representations, to solve these polynomial optimization problems. Their special properties and structures are studied. In applications, the resulting semidefinite programs are often large scale. The recent Newton-CG augmented Lagrangian method by Zhao, Sun, and Toh [SIAM J. Optim., 20 (2010), pp. 1737–1765] is suitable for solving these semidefinite relaxations. Extensive numerical experiments are presented to show that this approach is efficient in getting best rank-1 approximations.

We propose a variational approach to obtain superresolution images from multiple low-resolution frames extracted from video clips. First the displacement between the lowresolution frames and the reference frame are computed by an optical flow algorithm. Then a low-rank model is used to construct the reference frame in high-resolution by incorporating the information of the low-resolution frames. The model has two terms: a 2-norm data fidelity term and a nuclear-norm regularization term. Alternating direction method of multipliers is used to solve the model. Comparison of our methods with other models on synthetic and real video clips show that our resulting images are more accurate with less artifacts. It also provides much finer and discernable details.

The Mumford–Shah model is one of the most important image segmentation models and has been studied extensively in the last twenty years. In this paper, we propose a two-stage segmentation method based on the Mumford–Shah model. The first stage of our method is to find a smooth solution g to a convex variant of the Mumford–Shah model. Once g is obtained, then in the second stage the segmentation is done by thresholding g into different phases. The thresholds can be given by the users or can be obtained automatically using any clustering methods. Because of the convexity of the model, g can be solved efficiently by techniques like the split-Bregman algorithm or the Chambolle–Pock method. We prove that our method is convergent and that the solution g is always unique. In our method, there is no need to specify the number of segments K (K ≥ 2) before finding g. We can obtain any K-phase segmentations by choosing (K − 1) thresholds after g is found in the first stage, and in the second stage there is no need to recompute g if the thresholds are changed to reveal different segmentation features in the image. Experimental results show that our two-stage method performs better than many standard two-phase or multiphase segmentation methods for very general images, including antimass, tubular, MRI, noisy, and blurry images.