We prove the Wigner-Dyson-Mehta conjecture at fixed energy in the bulk of the spectrum for generalized symmetric and Hermitian Wigner matrices. Previous results concerning the universality of random matrices either require an averaging in the energy parameter or they hold only for Hermitian matrices if the energy parameter is fixed. We develop a homogenization theory of the Dyson Brownian motion and show that microscopic universality follows from mesoscopic statistics

We consider sample covariance matrices of the form $X^*X$, where $X$ is an $M times N$ matrix with independent random entries. We prove the isotropic local Marchenko-Pastur law, i.e. we prove that the resolvent $(X^* X - z)^{-1}$ converges to a multiple of the identity in the sense of quadratic forms. More precisely, we establish sharp high-probability bounds on the quantity $langle v, (X^* X - z)^{-1} w rangle - langle v,w rangle m(z)$, where $m$ is the Stieltjes transform of the Marchenko-Pastur law and $v, w in mathbb C^N$. We require the logarithms of the dimensions $M$ and $N$ to be comparable. Our result holds down to scales $Im z geq N^{-1+epsilon}$ and throughout the entire spectrum away from 0. We also prove analogous results for generalized Wigner matrices.

The stochasticity of gene expression is manifested in the fluctuations of mRNA and protein copy numbers within a cell lineage over time. While data of this type can be obtained for many generations, most mathematical models are unsuitable to interpret such data since they assume non-growing cells. Here we develop a theoretical approach that quantitatively links the frequency content of lineage data to subcellular dynamics. We elucidate how the position, height, and width of the peaks in the power spectrum provide a distinctive fingerprint that encodes a wealth of information about mechanisms controlling transcription, translation, replication, degradation, bursting, promoter switching, cell cycle duration, cell division, gene dosage compensation, and cell size homeostasis. Predictions are confirmed by analysis of single-cell Escherichia coli data obtained using fluorescence microscopy. Furthermore, by matching the experimental and theoretical power spectra, we infer the temperature-dependent gene expression parameters, without the need of measurements relating fluorescence intensities to molecule numbers.

We derive the alternating arm exponents of the critical Ising model. We obtain six different patterns of alternating boundary arm exponents which correspond to the boundary conditions (⊖⊕), (⊖ free) and (free free), and the alternating interior arm exponents.

A fundamental and very well studied region of the Erdős–Rényi process is the phase transition at$m$∼$n$/2 edges in which a giant component suddenly appears. We examine the process beginning with an initial graph. We further examine the Bohman–Frieze process in which edges between isolated vertices are more likely. While the positions of the phase transitions vary, the three processes belong, roughly speaking, to the same universality class. In particular, the growth of the giant component in the barely supercritical region is linear in all cases.