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The stochasticity of gene expression is manifested in the fluctuations of mRNA and protein copy numbers within a cell lineage over time. While data of this type can be obtained for many generations, most mathematical models are unsuitable to interpret such data since they assume non-growing cells. Here we develop a theoretical approach that quantitatively links the frequency content of lineage data to subcellular dynamics. We elucidate how the position, height, and width of the peaks in the power spectrum provide a distinctive fingerprint that encodes a wealth of information about mechanisms controlling transcription, translation, replication, degradation, bursting, promoter switching, cell cycle duration, cell division, gene dosage compensation, and cell size homeostasis. Predictions are confirmed by analysis of single-cell Escherichia coli data obtained using fluorescence microscopy. Furthermore, by matching the experimental and theoretical power spectra, we infer the temperature-dependent gene expression parameters, without the need of measurements relating fluorescence intensities to molecule numbers.

The tip multifractal spectrum of a 2-dimensional curve is one way to describe the behavior of the uniformizing conformal map of the complement near the tip. We give the tip multifractal spectrum for a Schramm–Loewner evolution (SLE) curve, we prove that the spectrum is valid with probability 1, and we give applications to the scaling of harmonic measure at the tip.

We prove that uniform random quadrangulations of the sphere with$n$faces, endowed with the usual graph distance and renormalized by$n$^{−1/4}, converge as$n$→$∞$in distribution for the Gromov–Hausdorff topology to a limiting metric space. We validate a conjecture by Le Gall, by showing that the limit is (up to a scale constant) the so-called$Brownian map$, which was introduced by Marckert–Mokkadem and Le Gall as the most natural candidate for the scaling limit of many models of random plane maps. The proof relies strongly on the concept of$geodesic stars$in the map, which are configurations made of several geodesics that only share a common endpoint and do not meet elsewhere.

We consider sample covariance matrices of the form $X^*X$, where $X$ is an $M times N$ matrix with independent random entries. We prove the isotropic local Marchenko-Pastur law, i.e. we prove that the resolvent $(X^* X - z)^{-1}$ converges to a multiple of the identity in the sense of quadratic forms. More precisely, we establish sharp high-probability bounds on the quantity $langle v, (X^* X - z)^{-1} w rangle - langle v,w rangle m(z)$, where $m$ is the Stieltjes transform of the Marchenko-Pastur law and $v, w in mathbb C^N$. We require the logarithms of the dimensions $M$ and $N$ to be comparable. Our result holds down to scales $Im z geq N^{-1+epsilon}$ and throughout the entire spectrum away from 0. We also prove analogous results for generalized Wigner matrices.