This paper considers a proportional hazards model, which allows one to examine the extent to which covariates interact nonlinearly with an exposure variable, for analysis of lifetime data. A local partial-likelihood technique is proposed to estimate nonlinear interactions. Asymptotic normality of the proposed estimator is established. The baseline hazard function, the bias and the variance of the local likelihood estimator are consistently estimated. In addition, a one-step local partial-likelihood estimator is presented to facilitate the computation of the proposed procedure and is demonstrated to be as efficient as the fully iterated local partial-likelihood estimator. Furthermore, a penalized local likelihood estimator is proposed to select important risk variables in the model. Numerical examples are used to illustrate the effectiveness of the proposed procedures.

Multiple hypothesis testing is a fundamental problem in high dimensional inference, with wide applications in many scientific fields. In genome-wide association studies, tens of thousands of tests are performed simultaneously to find if any genes are associated with some traits and those tests are correlated. When test statistics are correlated, false discovery control becomes very challenging under arbitrary dependence. In the current paper, we propose a new methodology based on principal factor approximation, which successfully substracts the common dependence and weakens significantly the correlation structure, to deal with an arbitrary dependence structure. We derive the theoretical distribution for false discovery proportion (FDP) in large scale multiple testing when a common threshold is used and provide a consistent FDP. This result has important applications in controlling FDR and FDP. Our estimate of FDP compares favorably with Efron (2007)'s approach, as demonstrated by in the simulated examples. Our approach is further illustrated by some real data applications.

Largescale multiple testing with correlated test statistics arises frequently in much scientific research. Incorporating correlation information in approximating the false discovery proportion (FDP) has attracted increasing attention in recent years. When the covariance matrix of test statistics is known, Fan and his colleagues provided an accurate approximation of the FDP under arbitrary dependence structure and some sparsity assumption. However, the covariance matrix is often unknown in many applications and such dependence information must be estimated before approximating the FDP. The estimation accuracy can greatly affect the FDP approximation. In the current paper, we study theoretically the effect of unknown dependence on the testing procedure and establish a general framework such that the FDP can be well approximated. The effects of unknown dependence on approximating the FDP are in the

We propose to model multivariate volatility processes on the basis of the newly defined conditionally uncorrelated components (CUCs). This model represents a parsimonious representation for matrixvalued processes. It is flexible in the sense that each CUC may be fitted separately with any appropriate univariate volatility model. Computationally it splits one high dimensional optimization problem into several lower dimensional subproblems. Consistency for the estimated CUCs has been established. A bootstrap method is proposed for testing the existence of CUCs. The methodology proposed is illustrated with both simulated and real data sets.

We extend the idea of crossvalidation to choose the smoothing parameters of the double-kernel local linear regression for estimating a conditional density. Our selection rule optimises the estimated conditional density function by minimising the integrated squared error. We also discuss three other bandwidth selection rules, an ad hoc method used by Fan et al. (1996), a bootstrap method of Hall et al. (1999) for bandwidth selection in the estimation of conditional distribution functions, modified by Bashtannyk & Hyndman (2001) to cover conditional density functions, and finally a simple approach proposed by Hyndman & Yao (2002). The performance of the new approach is compared with these three methods by simulation studies, and our method performs outstandingly well. The method is illustrated by an application to estimating the transition density and the Value-at-Risk of treasury-bill data.