Structural variations in genome could be more critical than SNP (Single-Nucleotide Polymorphism) in causing tumor cells, immune system diseases and fatness. It is necessary and important to detect structural variations with next generation sequencing data by means of efficient and accurate algorithms. This paper introduced a new algorithm using k-mers (short fragments of genome), string algorithms and graph algorithms, which combines similarity check, variation detection with sequence assembly. Our results showed that our method has high accuracy and it is more reliable than methods using reference and more efficient than popular algorithms.

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This research, initiated by a problem excerpted from Baidu, one of the most famous internet search engines in China, explores two types of movements, “converging curve” and “tracing curve” named by this research group, which really act in a regular pattern. In the research, by applying scores of mathematical methods, we found that the key to converging curves is to spot the invariant elements from the changeful motions. For tracing curves, we adopt estimating equations to get the solution. Due to the limit of time and the relevant knowledge of the research group, many unexpected problems constantly appeared which are quite far beyond our ability. Yet we still tried to apply some promising mathematical thoughts, and have achieved some exciting results. In the process of discovering and rediscovering, we did not succeed in finding a perfect solution to the problem. After all, as a group of middle school students fascinated by mathematics, creating and discovering more are the greatest delight of us all.

Characterization of homogeneous polynomials with isolated critical point at the origin follows from a study of complex geometry. Yau previously proposed a Numerical Characterization Conjecture. A step forward in solving this Conjecture, the Granville-Lin-Yau Conjecture was formulated, with a sharp estimate that counts the number of positive integral points in ndimensional (n≥3) real right-angled simplices with vertices whose distance to the origin are at least n-1. The estimate was proven for n≤6 but has a counterexample for n = 7. In this project we come up with an idea of forming a new sharp estimate conjecture where we need the distances of the vertices to be n. We have proved this new sharp estimate conjecture for n≤7 and are in the process of proving the general n case.

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