In this paper, we present an efficient attack on the multivariate Quadratic Quasigroups (MQQ) public key cryptosystem. Our cryptanalysis breaks the MQQ cryptosystem by solving a system of multivariate quadratic polynomial equations using both the MutantXL algorithm and the F4 algorithm. We present the experimental results that show that MQQ systems is broken up to size n equal to 300. Based on these results we show also that MutantXL solves MQQ systems with much less memory than the F4 algorithm implemented in Magma.