We investigate a class of generalized Schrdinger operators in L<sup>2</sup>(<sup>3</sup>) with a singular interaction supported by a smooth curve . We find a strong-coupling asymptotic expansion of the discrete spectrum in the case when is a loop or an infinite bent curve which is asymptotically straight. It is given in terms of an auxiliary one-dimensional Schrdinger operator with a potential determined by the curvature of . In the same way, we obtain asymptotics of spectral bands for a periodic curve. In particular, the spectrum is shown to have open gaps in this case if is not a straight line and the singular interaction is strong enough.