Let <i>M</i> be a compact Khler manifold and <i>N</i> be a subvariety with codimension greater than or equal to 2. We show that there are no complete KhlerEinstein metrics on M - N . As an application, let <i>E</i> be an exceptional divisor of <i>M</i>. Then M - N cannot admit any complete KhlerEinstein metric if blow-down of <i>E</i> is a complex variety with only canonical or terminal singularities. A similar result is shown for pairs.