There is an unmet medical need to identify neuroimaging biomarkers that allow us to accurately diagnose and monitor Alzheimer's disease (AD) at its very early stages and to assess the response to AD-modifying therapies. To a certain extent, volumetric and functional magnetic resonance imaging (fMRI) studies can detect changes in structure, cerebral blood flow, and blood oxygenation that distinguish AD and mild cognitive impairment (MCI) subjects from healthy control (HC) subjects. However, it has been challenging to use fully automated MRI analytic methods to identify potential AD neuroimaging biomarkers. We have thus proposed a method based on independent component analysis (ICA) for studying potential AD-related MR image features that can be coupled with the use of support vector machine (SVM) for classifying scans into categories of AD, MCI, and HC subjects. The MRI data were selected from

In this paper, we extend our previous work to construct (0, 2) Toda-like mirrors to A/2-twisted theories on more general spaces, as part of a program of understanding (0,2) mirror symmetry. Specifically, we propose (0, 2) mirrors to GLSMs on toric del Pezzo surfaces and Hirzebruch surfaces with deformations of the tangent bundle. We check the results by comparing correlation functions, global symmetries, as well as geometric blowdowns with the corresponding (0, 2) Toda-like mirrors. We also briefly discuss Grassmannian manifolds.

Let X be a compact complex, not necessarily K¨ahler, manifold of dimension n. We characterize the volume of any holomorphic line bundle L → X as the supremum R of the Monge-Amp`ere masses X Tn ac over all closed positive currents T in the first Chern class of L, where Tac is the absolutely continuous part of T in its Lebesgue decomposition. This result, new in the non-K¨ahler context, can be seen as holomorphic Morse inequalities for the cohomology of high tensor powers of line bundles endowed with arbitrarily singular Hermitian metrics. It gives, in particular, a new bigness criterion for line bundles in terms of existence of singular Hermitian metrics satisfying positivity conditions. The proof is based on the construction of a new regularization for closed (1, 1)-currents with a control of the Monge-Amp`ere masses of the approximating sequence. To this end, we prove a potential-theoretic result in one complex variable and study the growth of multiplier ideal sheaves associated with increasingly singular metrics.

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