Tumor growth and metastasis require that tumor cells must have either the potential to shift genetically or epigenetically between proliferative and invasive phenotypes or both phenotypes simultaneously. In the present study, we demonstrated that neuroblastoma growth and invasion were distinct processes that were carried out by proliferative and invasive phenotypes of tumor cells, respectively. Two subpopulations from human neuroblastoma cell line were isolated: highly invasive (HI) cells and low-invasive (LI) cells. HI and LI cells had different proliferative rate and metastatic ability <i>in vitro</i> and <i>in vivo</i> . In addition, they had distinct activated signal pathways and sensitivities to chemotherapy drugs. Affymetrix microarray and quantitative reverse transcriptasepolymerase chain reaction revealed that visinin-like protein-1 (VSNL-1) mRNA in HI cells was significantly higher than

We study various geometrical quantities for CalabiYau varieties realized as cones over Gorenstein Fano varieties, obtained as toric varieties from reflexive polytopes in various dimensions. Focus is made on reflexive polytopes up to dimension 4 and the minimized volumes of the SasakiEinstein base of the corresponding CalabiYau cone are calculated. By doing so, we conjecture new bounds for the SasakiEinstein volume with respect to various topological quantities of the corresponding toric varieties. We give interpretations about these volume bounds in the context of associated field theories via the AdS/CFT correspondence.

The diameter of a disc filling a loop in the universal covering of a Riemannian manifold M may be measured extrinsically using the distance function on the ambient space or intrinsically using the induced length metric on the disc. Correspondingly, the diameter of a van Kampen diagram
filling a word that represents the identity in a finitely presented group 􀀀 can either be measured intrinsically in the 1–skeleton of
or extrinsically in the Cayley graph of 􀀀. We construct the first examples of closed manifolds M and finitely presented groups 􀀀 = π1M for which this choice — intrinsic versus extrinsic — gives rise to qualitatively different min–diameter filling functions.

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