Multiple hypothesis testing is a fundamental problem in high dimensional inference, with wide applications in many scientific fields. In genome-wide association studies, tens of thousands of tests are performed simultaneously to find if any genes are associated with some traits and those tests are correlated. When test statistics are correlated, false discovery control becomes very challenging under arbitrary dependence. In the current paper, we propose a new methodology based on principal factor approximation, which successfully substracts the common dependence and weakens significantly the correlation structure, to deal with an arbitrary dependence structure. We derive the theoretical distribution for false discovery proportion (FDP) in large scale multiple testing when a common threshold is used and provide a consistent FDP. This result has important applications in controlling FDR and FDP. Our estimate of FDP compares favorably with Efron (2007)'s approach, as demonstrated by in the simulated examples. Our approach is further illustrated by some real data applications.

Two-dimensional localized edge modes in optical honeycomb lattices are found and analyzed analytically and computationally. Weak nonlinearity and transverse modulation are found to introduce self-phase modulation in the phase and create internal nonlinear interactions as the electromagnetic field propagates through the lattice. Even with relatively strong nonlinearity localization and persistence of modes along the edge are found.

Convolutional neural networks have been widely deployed in various application scenarios. In order to extend the applications’ boundaries to some accuracy-crucial domains, researchers have been investigating approaches to boost accuracy through either deeper or wider network structures, which brings with them the exponential increment of the computational and storage cost, delaying the responding time. In this paper, we propose a general training framework named self distillation, which notably enhances the performance (accuracy) of convolutional neural networks through shrinking the size of the network rather than aggrandizing it. Different from traditional knowledge distillation - a knowledge transformation methodology among networks, which forces student neural networks to approximate the softmax layer outputs of pre-trained teacher neural networks, the proposed self distillation framework distills knowledge within network itself. The networks are firstly divided into several sections. Then the knowledge in the deeper portion of the networks is squeezed into the shallow ones. Experiments further prove the generalization of the proposed self distillation framework: enhancement of accuracy at average level is 2.65%, varying from 0.61% in ResNeXt as minimum to 4.07% in VGG19 as maximum. In addition, it can also provide flexibility of depth-wise scalable inference on resource-limited edge devices. Our codes have been released on github. https://github.com/ArchipLab-LinfengZhang/ pytorch-self-distillation.

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