In this paper, we consider the numerical approximation of the three-dimensional poroelastic wave equations in the spherical coordinate system. One difficulty in the design of an efficient numerical scheme is that the problem is singular in the center and the polar axes of the computational domain. Nevertheless, we develop a hybrid finite difference/control volume method for solving this problem. Our method is explicit and is second order accurate in both space and time. Numerical results are shown to confirm the convergence rate of our method and the effectiveness to simulate wave propagation in poroelastic media in the spherical coordinate system.

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In this paper, we first present a theoretical analysis model on the Proof-of-Work (PoW) for cryptocurrency blockchain. Based on this analysis, we present a new type of PoW, which relies on the hardness of solving a set of random quadratic equations over the finite field GF(2). We will present the advantages of such a PoW, in particular, in terms of its impact on decentralization and the incentives involved, and therefore demonstrate that this is a new good alternative as a new type for PoW in blockchain applications.

This book presents an overview of recent developments in biostatistics and bioinformatics. Written by active researchers in these emerging areas, it is intended to give graduate students and new researchers an idea of where the frontiers of biostatistics and bioinformatics are as well as a forum to learn common techniques in use, so that they can advance the fields via developing new techniques and new results. Extensive references are provided so that researchers can follow the threads to learn more comprehensively what the literature is and to conduct their own research. In particulars, the book covers three important and rapidly advancing topics in biostatistics: analysis of survival and longitudinal data, statistical methods for epidemiology, and bioinformatics.