We study in this work a continuum model derived from 1D attachment-detachment-limited (ADL) type step flow on vicinal surface, $ u_t=-u^2(u^3)_{hhhh}$, where $u$, considered as a function of step height $h$, is the step slope of the surface. We formulate a notion of weak solution to this continuum model and prove the existence of a global weak solution, which is positive almost everywhere. We also study the long time behavior of weak solution and prove it converges to a constant solution as time goes to infinity. The space-time H\"older continuity of the weak solution is also discussed as a byproduct.

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We study convolution groups generated by completely monotone sequences and completely monotone functions. Using a convolution group, we define a fractional calculus for a certain class of distributions. When acting on causal functions, this definition agrees with the traditional Riemann-Liouville definition for t>0 but includes some singularities at t=0 so that the group property holds. Using this group, we are able to extend the definition of Caputo derivatives of order in (0,1) to a certain class of locally integrable functions without using the first derivative. The group property allows us to de-convolve the fractional differential equations to integral equations with completely monotone kernels, which then enables us to prove the general Gronwall inequality (or comparison principle) with the most general conditions. This then opens the door of a priori energy estimates of fractional PDEs. Some other fundamental results for fractional ODEs are also established within this frame under very weak conditions. Besides, we also obtain some interesting results about completely monotone sequences.

Zika virus (ZIKV) is a mosquito-borne flavivirus. It was first isolated from Uganda in 1947 and has become an emergent event since 2007. However, because of the inconsistency of alignment methods, the evolution of ZIKV remains poorly understood. In this study, we first use the complete protein and an alignment-free method to build a phylogenetic tree of 87 Zika strains in which Asian, East African, and West African lineages are characterized. We also use the NS5 protein to construct the genetic relationship among 44 Zika strains. For the first time, these strains are divided into two clades: African 1 and African 2. This result suggests that ZIKV originates from Africa, then spread to Asia, Pacific islands, and throughout the Americas. We also perform the phylogeny analysis for 53 viruses in genus Flavivirus to which ZIKV belongs using complete proteins. Our conclusion is consistent with the classification by the hosts and transmission vectors.