A comprehensive description of human genomes is essential for understanding human evolution and relationships between modern populations. However, most published literature focuses on local alignment comparison of several genes rather than the complete evolutionary record of individual genomes. Combining with data from the 1,000 Genomes Project, we successfully reconstructed 2,504 individual genomes and propose Divided Natural Vector method to analyze the distribution of nucleotides in the genomes. Comparisons based on autosomes, sex chromosomes and mitochondrial genomes reveal the genetic relationships between populations, and different inheritance pattern leads to different phylogenetic results. Results based on mitochondrial genomes confirm the “out-of-Africa” hypothesis and assert that humans, at least females, most likely originated in eastern Africa. The reconstructed genomes are stored on our server and can be further used for any genome-scale analysis of humans (http://yaulab.math.tsinghua.edu.cn/2022_1000genomesprojectdata/). This project provides the complete genomes of thousands of individuals and lays the groundwork for genome-level analyses of the genetic relationships between populations and the origin of humans.

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For a compact connected set$X$⊆$ℓ$^{∞}, we define a quantity$β$′($x$,$r$) that measures how close$X$may be approximated in a ball$B$($x$,$r$) by a geodesic curve. We then show that there is$c$>0 so that if$β$′($x$,$r$)>$β$>0 for all$x$∈$X$and$r$<$r$_{0}, then $\operatorname{dim}X>1+c\beta^{2}$ . This generalizes a theorem of Bishop and Jones and answers a question posed by Bishop and Tyson.

In this paper, we provide existence and estimates of the equation du A v^du i= i

In this paper, we develop a class of nonlinear compact schemes based on our previous linear central compact schemes with spectral-like resolution [X. Liu, S. Zhang, H. Zhang and C-W. Shu, A new class of central compact schemes with spectral-like resolution I: Linear schemes, Journal of Computational Physics 248 (2013) 235-256]. In our approach, we compute the flux derivatives on the cell-nodes by the physical fluxes on the cell nodes and numerical fluxes on the cell centers. To acquire the numerical fluxes on the cell centers, we perform a weighted hybrid interpolation of an upwind interpolation and a central interpolation. Through systematic analysis and numerical tests, we show that our nonlinear compact scheme has high order, high resolution and low dissipation, and has the same ability to capture strong discontinuities as regular weighted essentially non-oscillatory (WENO) schemes. It is a good choice for the simulation of multiscale problems with shock waves.